The author documents an indigenous smallpox inoculation practice in the East Indies, outlining the procedural steps, the itinerant specialists who perform them, and the seasonal planning of their circuits. He reports local epidemiology, including cyclical malignant outbreaks, variations in mortality among different groups, and speculative links to diet and environment. The account describes prevailing beliefs and resistance to the practice, contrasts native methods with contemporary European approaches, offers observations on treatment and outcomes, and argues that knowledge of this foreign technique can inform and improve current inoculation practice.