[K] Medico-Actuarial Mortality Investigation, Volume II, page 13, compiled and published by The Association of Life Insurance Medical Directors and The Actuarial Society of America.
[L] The standard death rate is that experienced by average insurance risks of the same age, according to the Medico-Actuarial Committee.
It seems reasonable to deduce from these figures that the usual gain in weight with advancing years is not an advantage but a handicap. We should endeavor to keep our weight at approximately the average weight for age 30, the period of full maturity, as experience shows that those so proportioned exhibit the most favorable mortality. This weight, for the various heights, is shown in the following table:
| Height. | Pounds. | Height. | Pounds. | Height. | Pounds. | |||
|---|---|---|---|---|---|---|---|---|
| Ft. | In. | Ft. | In. | Ft. | In. | |||
| 5 | 126 | 5 | 7 | 148 | 6 | 1 | 178 | |
| 5 | 1 | 128 | 5 | 8 | 152 | 6 | 2 | 184 |
| 5 | 2 | 130 | 5 | 9 | 156 | 6 | 3 | 190 |
| 5 | 3 | 133 | 5 | 10 | 161 | 6 | 4 | 196 |
| 5 | 4 | 136 | 5 | 11 | 166 | 6 | 5 | 201 |
| 5 | 5 | 140 | 6 | 172 | .......... | ......... | ||
| 5 | 6 | 144 | ....... | ...... | .......... | ......... | ||
| Height. | Pounds. | Height. | Pounds. | Height. | Pounds. | |||
|---|---|---|---|---|---|---|---|---|
| Ft. | In. | Ft. | In. | Ft. | In. | |||
| 4 | 8 | 112 | 5 | 2 | 124 | 5 | 8 | 146 |
| 4 | 9 | 114 | 5 | 4 | 127 | 5 | 9 | 150 |
| 4 | 10 | 116 | 5 | 4 | 131 | 5 | 10 | 154 |
| 4 | 11 | 118 | 5 | 5 | 134 | 5 | 11 | 157 |
| 5 | 120 | 5 | 6 | 138 | 6 | 161 | ||
| 5 | 1 | 122 | 5 | 7 | 142 | .......... | ......... | |
In fat people, the number of working cells is relatively less in proportion to the weight than in thin people, as fat cells do not work. Also, there is less body surface exposed in proportion to the body weight, and consequently less heat loss. Likewise, fat people are less active, and their little cell-engines do not call for so much fuel; but in most cases the fuel is furnished right along in the ordinary diet, and what is not burned up is stored up.
For extreme overweight, diet should be prescribed accurately by the physician to suit the needs of each individual case. Certain general principles may be stated, however, as applicable to the average case.
Meals should be light and frequent, rather than hearty and infrequent. A little fruit may be taken on rising and a glass of hot water.
A light breakfast is advisable; one or two poached eggs, no sugar, bread and butter in small quantity.
For dinner, choice may be made of chicken, game, lean meat, fish not cooked in fat, in moderate portions, and of such vegetables as celery, spinach, sea-kale, lettuce, string beans, cucumbers, carrots, tomatoes, cabbage, Brussels sprouts, turnips, bulky vegetables of low food value. Tapioca or similar pudding may be used for desserts, and melon, and other cooked unsweetened fruits.
A glass of hot water on retiring is advisable.
It is surprising what an enormous fuel value certain foods have which are eaten very carelessly, and what a very low fuel value others have which are quite satisfying to hunger. For example: One would have to eat $9.00 worth of lettuce and tomato salad to furnish 2,500 calories, the amount of fuel for the day’s requirements (Lusk), while about 30 cents’ worth of butter, or 10 cents’ worth of sugar would furnish the same amount of energy. No one would think of feeding exclusively on any one of these foods, but it is easy to see how the elimination of butter and sugar and the introduction of such foods as lettuce, tomatoes, celery, carrots, spinach and fruits, all of which have a low fuel value, would enormously reduce the available energy and therefore the fat-forming elements in the diet, yet fill the stomach and satisfy the hunger-craving. Hunger is largely dependent upon the contractions of the empty stomach and not upon a general bodily craving for food.
Foods to avoid, in cases of overweight, are sugar, fats, milk as a beverage, salmon, lobster, crabs, sardines, herring, mackerel, pork and goose, fat meats, nuts, butter, cream, olive oil, pastry and sweets, water at meals. Alcohol, which is not a food, although often so called, should be avoided, as it is a fuel. It is good to burn in a stove, but not in the human body.
Walking, swimming, golf, billiards, hill-climbing, are all beneficial forms of exercise for the middle-aged and elderly, who are chiefly affected by overweight.
Irksome and monotonous forms of exercise, while difficult to follow regularly, are usually of more benefit, as they are less likely to create an appetite. Simple exercises, if repeated from twenty to forty times, night and morning, will accomplish much. No apparatus is required, and any movements that bring into play the entire muscular system, and especially the muscles of the trunk, with deep breathing, are sufficient. (See “Setting-up” exercises described in the “Notes on Posture,” page 221.) The main reliance should be upon dietetic regulation rather than upon exercise. A very moderate increase of exercise and a persistent adherence to a proper diet will work wonders in weight reduction.
It is unwise to attempt a sudden reduction in weight. Profound nervous depression may be caused by too rapid reduction in people of nervous temperament, especially if they have long been overweight. By gradually modifying the diet and moderately increasing the exercise, the results can be obtained with mathematical precision and without undue hardship. It may be necessary to forego certain pet dietetic indulgences, but such indulgences, are, after all, a mere matter of habit and a liking for new forms of food can usually be acquired. One can not have the cake and penny too. One can not safely reduce one’s weight by any mysterious method that will leave one at liberty to continue the indulgences, whether of sloth or of appetite, that are responsible for its accumulation.
The reduction of weight is really a very simple matter. No mysterious or elaborate “systems” or drugs are needed.
If a reduction in the amount of energy food and an increase in the amount of exercise is made, no power on earth can prevent a reduction in weight.
Even a sedentary worker uses up about 2,500 calories a day. By reducing the food to 1,200 calories (this can be done without decreasing its bulk) and increasing the exercise to the point of burning up 3,000 calories, the tissues are drawn upon for the difference, and a reduction in weight must be experienced just as surely as a reduction in a bank account is made by drawing checks on it.
MEN—UNDER AVERAGE WEIGHT
| Ages at Entry | Underweight, 5 to 10 lbs. |
Underweight, 15 to 20 lbs. |
Underweight, 25 to 45 lbs. |
|||
|---|---|---|---|---|---|---|
| Death Rate Below Stand- ard.[N] |
Death Rate Above Stand- ard. |
Death Rate Below Stand- ard. |
Death Rate Above Stand- ard. |
Death Rate Below Stand- ard. |
Death Rate Above Stand- ard. |
|
| 20–24 | ...... | 7% | ...... | 15% | ...... | 34% |
| 25–29 | 1% | ...... | ...... | 8% | ...... | 16% |
| 30–34 | ...... | 4% | ...... | 0% | ...... | 8% |
| 35–39 | 9% | ...... | ...... | 3% | ...... | 2% |
| 40–44 | 15% | ...... | 13% | ...... | 3% | ...... |
| 45–49 | 3% | ...... | 1% | ...... | 11% | ...... |
| 50–56 | 10% | ...... | 8% | ...... | 9% | ...... |
| 57–62 | 7% | ...... | 18% | ...... | 19% | ...... |
The most favorable mortality (19 per cent. below the average) is found among those aged 57 to 62 who are extremely light in weight, compared with the average weight for those ages. The next lowest mortality in any other age group (15 per cent. below the average) is among those aged 40 to 44 who are 5 to 10 pounds under the average weight.
[M] Medico-Actuarial Mortality Investigation, Volume 11, page 10.
[N] The standard death rate is that experienced by average insurance risks of the same age, according to the Medico-Actuarial Committee.
Thin people lose heat more readily than stout people, as they have a larger percentage of active tissue and expose more skin surface in proportion to the body weight. They require, therefore, an abundant supply of energy food, or fuel foods, fats, starch and sugar. Butter and olive oil are better than other fats and less likely to disturb the digestion. Sugar is a valuable fuel food, but should not be taken in concentrated form into an empty stomach. Sweets are best taken at the end of a meal, but in such cases the teeth should be well cleansed. Fruit at the end of a meal tends to prevent any injury to the teeth from sugar and starches.
Potatoes, cereals, bread and all starchy vegetables are fattening, but should be well chewed and tasted before swallowing. Thin, anemic people derive much benefit from egg lemonade or egg-nogs (without alcohol) made from the yolks, which contain fat, iron and other valuable elements.
Overfatigue and exhausting physical exertion should be avoided.
Moderate systematic exercises, with deep breathing, and sleeping out of doors, or approaching as near to it as one can, are advisable. At middle life and after, underweight, unless extreme or accompanied by evidence of impaired health, should not give any concern. Other things being equal, the old motto “A lean horse for a long race,” holds good.
SECTION III
NOTES ON POSTURE
Among simple exercises recommended for strengthening the abdominal muscles and restoring the organs to normal position are the following:
Lie flat on the back and rise to a sitting posture; squat until the thighs rest upon the calves of the legs. Lie flat on the back, head downward on an inclined plane (an ironing board, uptilted, will do) and make a bridge at intervals by arching the abdomen and resting on shoulders and heels.
From the fundamental standing posture described in this section, a number of exercises can be developed.
1. Yard-arm.—While deeply inhaling (through the nose) slowly raise the arms to horizontal position, straight out from the sides; let the arms fall slowly to the sides while exhaling. The chest should be well arched forward, hips drawn backward and arms hung back of thighs while performing this exercise.
These movements should be performed at the rate of about 10 per minute.
3. Tree-swaying.—While in the standing position, thrust the arms straight above the head, then sway from side to side, moving from the hips upward, the arms loosely waving like the branches of a tree. (Sargent.)
4. Leg-lifting.—Assume the standing position, but with hands resting on the hips. Raise the right thigh until at right angles with the body, leg at right angles with thigh, thrust the leg straightforward to a horizontal position, then sweep the leg back to standing posture. Repeat with the left leg. (Sargent.)
5. Signal Station.—Assume the standing posture with hands on hips. Thrust the right arm straight upward, while lifting the left leg outward and upward and rigidly extended. Lower the limbs and repeat on other side. (Sargent.)
6. Crawling Position.—Rest on hands and knees, thighs and arms at right angles to the body, spine straight. Reach forward with arm and follow with thigh and leg of same side; repeat on other side. Knee protectors can be worn during this exercise.
Draw two parallel chalk lines about three-fourths the length of one foot apart and practise walking on them until the habit of toeing straight is acquired.
When standing, do not keep the heels together and toes out, as in the ordinary attitude prescribed by athletic manuals, and the military attitude of “attention.” Correct posture is more like the military attitude “at rest”—namely, heels apart, toes straight forward, the sides of the feet forming two sides of a square. This attitude gives stability and poise and insures a proper distribution of the weight of the body upon the structures of the feet.
This straightforward direction of the feet with heels apart is also noted in Spartan sculpture.
Those who stand a great deal should avoid distorted positions, such as resting the weight on the sides of the feet, or on one foot with the body sagging to one side. The body weight should be kept evenly supported on both feet.
When the condition of flat foot is found, the advice of an Orthopedic surgeon (specialist on bone deformities, etc.) should be sought, as often a plaster cast of the foot is required in order that a proper brace be adjusted to assist in the cure. In some cases, operative treatment may be needed.
The condition is one which should be treated by a physician or surgeon, and not by a shoemaker. The ordinary arch supports supplied by shoemakers do not cure flat foot. Shoes for such feet should be made to order, and have a straight internal edge.
All such measures must be supplemented by proper exercises, and the correction of faulty position of the feet while walking.
Unless “toeing out” is corrected by exercise and a proper shoe, an arch brace will do more harm than good.
The disturbances of health due to weak feet are manifold, just as are those due to eye-strain. Pain in the feet, legs and back, often mistaken for rheumatism, and improperly treated with drugs and liniment, chronic general fatigue and nervous depression are often due to this rather common affection.
To detect weak feet, note whether there is a tendency to toe out when walking, and a bending inward of the ankles when standing or walking, or a disposition to walk on the inner side of the feet, as shown by the uneven wearing of the shoe. This condition may be present with a high instep, and no evidence of flat foot. As flat foot develops the inward bend of the ankle is easily apparent. The inner hollow of the foot disappears and the entire sole rests flat upon the ground when the shoes are removed.
The earlier in life this condition of weak feet is detected, the better for the individual. After middle life, a cure, especially in extremely heavy people, may be difficult or impossible, if the arches are completely broken down. Much relief, however, can be afforded by proper braces, fitted scientifically, by means of a plaster cast.
In young people, a cure can almost invariably be effected, and after a time braces and supports are not needed.
It is a very grave mistake to suppose that in such cases so-called arch supports will either cure flat foot or that people with weak feet are necessarily condemned to wear such supports throughout life.
The cure is sometimes effected in a short time, but it may take a year or two, and with proper management it can usually be accomplished, unless there is some unusual complication.
The prevention of flat foot consists largely in affording due exercise of the leg and foot muscles and tendons by plenty of walking and running, especially in childhood, and especially on rough ground. Flat pavements are, indirectly, one cause of flat foot.
SECTION IV
NOTES ON ALCOHOL
The influence of alcohol on longevity can be most satisfactorily determined by the records of life insurance companies wherein the death-rates among those abstaining from alcohol have been computed as compared to those of the general class of insured lives. In considering such figures it is well to bear in mind that the general or non-abstaining class comprises only those who were accepted as standard healthy risks and so far as could be determined were moderate in their use of alcohol. Such experiences have been carefully compiled by the following companies:
United Kingdom Temperance and General Provident Institution of London;[1][O] The Sceptre Life;[2] The Scottish Temperance Life of Glasgow;[3] The Abstainers and General Life of London;[4] The Manufacturers’ Life of Canada;[5] Security Mutual Life of Binghamton, N. Y.[6]
[O] The notes (“[1]” etc.) refer to the publications listed at the close of the section.
The comparative mortality among abstainers and non-abstainers in several of these companies is shown in the charts exhibited in this section.
It is probable that the heavier mortality among non-abstainers as compared to abstainers is not wholly due to the chemical effect of alcohol on the tissues, but in some degree to collateral excesses (especially those resulting in infection from the diseases of vice) and a more careless general manner of living engendered by alcoholic indulgence; that, furthermore, those who indulge in so-called moderation are open to greater temptation to increased indulgence and final excess than those who abstain altogether.
It has often been alleged, however, that the lower mortality among abstainers was due solely to a more conservative habit of living, and that this class is largely composed of people in favorable or preferred occupations, such as clergymen and teachers.
The experience of the Security Mutual of Binghamton, N. Y., does not support such a postulate. During a twelve years’ experience the mortality among the abstainers was one-third that of the tabular expectation, and their occupations were classified as follows:
| Clergymen | 4 | per cent. |
|---|---|---|
| Farmers | 19 | " " |
| Clerks | 15 | " " |
| Miscellaneous (earning $15 to $25 per week) | 62 | " " |
Mr. Roderick McKenzie Moore, Actuary of the United Kingdom Temperance and General Provident Institution,[7] has this to say regarding the abstainers’ class in that company:
The total abstainer class was not “nursed” or favored to produce a low mortality. So far as could be determined (and many of the risks came in personal contact with the officers) they were of the same general class as the non-abstainers. They were written by the same group of agents, for the same kind of policies, for the same average amounts, and were in the same general walks of life, and of the same general financial condition. They were almost equal in numbers to the general class and did not form a small high grade section of the policyholding body. On the contrary, greater care was exercised in the selection of the non-abstainers because of the less favorable experience anticipated on them, and many borderline risks were accepted in the abstaining class because of a feeling that their abstinence would neutralize some unfavorable factor.
UNITED KINGDOM TEMPERANCE AND GENERAL PROVIDENT INSTITUTION OF LONDON
HEALTHY MALES—WHOLE LIFE POLICIES
1866–1910
| EXPECTED MORTALITY | 100% | |
|---|---|---|
| NON-ABSTAINERS, RATIO ACTUAL TO EXPECTED MORTALITY | – – – – – – | 91% |
| [P]ABSTAINERS, RATIO ACTUAL TO EXPECTED MORTALITY | — - — - — | 66% |
MORTALITY AMONG NON-ABSTAINERS—STANDARD RISKS—37.7% HIGHER THAN AMONG ABSTAINERS
[P] THAT IS, WHERE—ACCORDING TO THE MORTALITY TABLES UPON WHICH PREMIUMS ARE BASED—100 WERE EXPECTED TO DIE, ONLY 66 ACTUALLY DIED.
SCEPTRE LIFE ASSOCIATION OF LONDON
WHOLE LIFE POLICIES
1884–1911
| EXPECTED MORTALITY | 100% | |
|---|---|---|
| NON-ABSTAINERS, RATIO ACTUAL TO EXPECTED MORTALITY | – – – – – – | 80% |
| ABSTAINERS, RATIO ACTUAL TO EXPECTED MORTALITY | — - — - — | 52% |
MORTALITY AMONG NON-ABSTAINERS—STANDARD RISKS—51.8% HIGHER THAN AMONG ABSTAINERS
THE LIFE EXTENSION INSTITUTE, INC.
THE SCOTTISH TEMPERANCE LIFE ASSURANCE CO. OF GLASGOW
HEALTHY MALES—WHOLE LIFE POLICIES
1883–1912
| EXPECTED MORTALITY | 100% | |
|---|---|---|
| NON-ABSTAINERS, RATIO ACTUAL TO EXPECTED MORTALITY | – – – – – – | 66% |
| ABSTAINERS, RATIO ACTUAL TO EXPECTED MORTALITY | — - — - — | 48% |
MORTALITY AMONG NON-ABSTAINERS—STANDARD RISKS—43.5% HIGHER THAN AMONG ABSTAINERS
COMPARATIVE MORTALITY AMONG USES OF ALCOHOL 43 AMERICAN LIFE INSURANCE COMPANIES 1885–1908
| DEATH RATE AMONG INSURED LIVES GENERALLY—MEDICO ACTUARIAL TABLE | 100 | ||||||||||||||||||||||||| |
|---|---|---|
| DEATH RATE AMONG POLICYHOLDERS USING 2 GLASSES OF BEER OR 1 GLASS OF WHISKEY DAILY | 118 | |||||||||||||||||||||||||||||| |
| DEATH RATE AMONG POLICYHOLDERS GIVING HISTORY OF PAST INTEMPERANCE, BUT APPARENTLY CURED | 150 | |||||||||||||||||||||||||||||||||||||| |
| DEATH RATE AMONG POLICYHOLDERS USING MORE THAN 2 GLASSES OF BEER OR 1 GLASS OF WHISKEY DAILY, BUT, REGARDED AS TEMPERATE & STANDARD RISKS | 186 | ||||||||||||||||||||||||||||||||||||||||||||||| |
Now that accurate laboratory evidence is available regarding the physiological effect of alcohol in so-called moderate doses the insurance experience seems consistent, and the higher mortality among so-called moderate drinkers is only what we would naturally expect to find in the light of the most recent knowledge regarding its effects upon the human organism, not only in the direct causation of disease, but in lowering the defense to disease and increasing the liability to accident, and the tendency to careless living.
In the recent medico-actuarial investigation[8], including forty-three American life insurance companies, the combined experience on users of alcohol has been compiled, with very interesting results. It may be subdivided as follows:
First: Those who were accepted as standard risks but who gave a history of occasional alcoholic excess in the past. The mortality in this group was 50 per cent. in excess of the mortality of insured lives in general, equivalent to a reduction of over four years in the average lifetime of the group.
Second: Individuals who took two glasses of beer, or a glass of whisky, or their alcoholic equivalent, each day. In this group the mortality was 18 per cent. in excess of the average.
Third: Men who indulge more freely than the preceding group, but who were considered acceptable as standard insurance risks. In this group the mortality was 86 per cent. in excess of the average. In short, we find the following increase of mortality over the average death rate among insured risks generally:
| Steady moderate drinkers but accepted as standard risks | 86 | per cent. |
| Having past excesses | 50 | " " |
| Very moderate drinkers | 18 | " " |
This means that steady drinkers who exceed two glasses of beer or one glass of whisky daily are not, on the evidence, entitled to standard insurance, but should be charged a heavy extra premium.
In these groups, the death rates from Bright’s disease, pneumonia and suicide were higher than the normal.
The per capita consumption of alcohol has greatly increased in the United States in recent years, while in the United Kingdom it has materially decreased, as shown in the following table. This factor must be considered in assigning a cause for the increasing mortality from degenerative diseases in this country as compared to a decreasing mortality from these maladies in Great Britain.
| 1896–1900. | 1908–1912. | |||||||
|---|---|---|---|---|---|---|---|---|
| Beer. | Wine. | Spirits. | Total. | Beer. | Wine. | Spirits. | Total. | |
| Germany | 25.4 | 1.37 | 1.66 | 28.43 | 22.4 | 1.09 | 1.29 | 24.78 |
| United Kingdom | 31.6 | .39 | 1.05 | 33.04 | 26.65 | .26 | .71 | 27.62 |
| France | 5.5 | 19.9 | 1.7 | 27.1 | 8.6 | 24.7 | 1.42 | 34.72 |
| United States | 13.01 | .30 | .81 | 14.12 | 16.62 | .52 | 1.02 | 18.16 |
Laboratory and Clinical Evidence Relating to the Physiological Effects of Alcohol
To interpret correctly the mortality statistics relating to moderate drinkers and total abstainers, one must have some knowledge of the physiological effects of alcohol in so-called moderate doses, a knowledge which is often lacking in those who assume to interpret such statistics.
For example: If it could be shown that small doses of alcohol produce no ascertainable ill effects upon the human organism, the higher mortality among the moderate drinkers as compared to total abstainers might have to be explained as due to some as yet unrecognized cause or causes other than alcohol. But if laboratory and clinical evidence shows that alcohol in so-called moderate quantities (social moderation) produces definite ill effects, such as lowering the resistance to disease, increasing the liability to accident and interfering with the efficiency of mind and body and thus lessening the chances for success in life, to say nothing of any toxic degenerative effect upon liver, kidneys, brain and other organs, the excess mortality that unquestionably obtains among moderate drinkers as compared to total abstainers must be ascribed chiefly to alcohol.
It is not possible here to give all the evidence, but the following items will serve to clarify these questions.
Kraepelin[10] and his pupils have contributed most extensively to our knowledge on this subject. According to such authorities, a half to a whole liter of beer is sufficient to lower intellectual power, to impair memory, and to retard simple mental processes, such as the addition of simple figures. Habitual association of ideas, and free association of ideas are interfered with.
As far back as 1895, Smith demonstrated the influence of small doses of alcohol in impairing memory, and these results have been confirmed by Kraepelin and quite recently by Vogt[11] in experiments on his own person—15 cc. (about 4 teaspoonfuls) of whisky on an empty stomach, or 25 cc. with food, being sufficient to distinctly impair the power to memorize.
Careful and exact experiments have shown the influence of moderate doses of alcohol in lessening the amount of work performed by printing compositors. There has also been shown a disturbance in the sequence of ideas. The time that elapses between an irritation and the beginning of a responsive movement can be measured within one one-thousandth of a second. According to Aschaffenburg,[12] under the influence of even very small doses of alcohol this reaction period is disturbed and shortened. It is below the normal, the acceleration being attained at the expense of precision and reliability. Indeed, the reaction is often premature, and constitutes a false reaction—“the judgment of the reason comes limping along after the hasty action.”
It is now conceded that alcohol is not a real brain stimulant, but acts by narrowing the field of consciousness. By gradually overcoming the higher brain elements the activities of the lower ones are released, hence the so-called stimulation and the lack of judgment and common sense often shown by those even slightly under the influence of alcohol. The man who wakes up under alcohol is really going to sleep, as far as his judgment and reason are concerned. Complete abolition of consciousness is brought about by sufficient doses as when ether or chloroform is taken.
Under moderate doses, muscular efficiency is at first increased a little and then lowered, the total effect being a loss in working power, as shown by the experiments of Dubois, Schnyder,[13] Hellsten,[14] and others.
Muller, Wirgin and others[15] have shown that alcohol restricts the formation of antibodies (the function of which is to resist infection in the blood) in rabbits, and Laitinen[16] has shown that the prolonged administration of small doses in men (15 cc.) is sufficient to lower vital resistance, especially to typhoid fever.
Rubin[17] has demonstrated that alcohol, ether and chloroform, injected under the skin, render rabbits more vulnerable to streptococcus (blood poison) and pneumnococcus infection (pneumonia); Stewart,[18] that small amounts lower the resistance to tuberculosis and streptococcus infection; Craig and Nichols,[19] that moderate doses of whisky were sufficient to cause a negative Wassermann reaction in syphilitic subjects; Fillinger[20] found the resistance of red blood cells much reduced after the administration of champagne to healthy human subjects. Similar results were found in dogs and rabbits.
Weinburg[21] confirmed these results by the same methods, showing that 20 per cent. of the red cells lose their resistance after the administration of 450 cc. of champagne.
Parkinson,[22] in a series of careful tests, failed to establish any influence on phagocytosis (capacity of the white blood cells to destroy bacteria), except when large doses or continuous moderate doses were taken.
On the heart and circulation, alcohol acts as a depressant, increasing the rate, but not the force, of the pulse. It causes depression of the nerve center controlling the blood vessels and thus lowers blood pressure. Large doses cause paralysis of these nerves and of the heart.
Miller and Brooks[23] found from small doses (6 to 12 cc. absolute alcohol) an increase in blood pressure in conscious (unanesthetized) animals, contrary to the findings of Crile,[24] Cabot,[25] Dennig,[26] Hindelang and Grünbaum, Alexandroff[27] and others, in man; but the amounts were small and variable, according to individual susceptibility, thus showing the drug to be, even on such evidence, uncertain and unserviceable as a heart stimulant.