The author reconstructs the life of a Renaissance noblewoman linked to a powerful papal dynasty by scrutinizing contemporary documents and correspondence, contrasting sensational accusations with archival evidence. The work traces her familial and political connections, the controversies and rumors that shaped her public image, and the historiographical debates that have alternately condemned or defended her. Emphasis is placed on documentary research in principal Italian archives and on situating episodes of intrigue within the wider context of papal politics and courtly alliances, aiming to reassess mythic portrayals through primary sources.