On the mechanism of the physiological action of the cathartics

Chapter 5: AUTHOR’S PREFACE.

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A series of controlled physiological experiments investigates how cathartic agents produce purgative effects, focusing on saline laxatives and plant extracts. Using animal preparations, isolated intestinal loops, and local application to peritoneal surfaces, the author examines changes in intestinal secretion and motility, systemic influences such as renal secretion, and the modifying roles of divalent salts. Evidence is marshaled that calcium and barium alter or counteract the action of saline cathartics, and the monograph compares mechanisms across different compounds while detailing methods and results.

AUTHOR’S PREFACE.

The following pages contain an account of a long series of experiments made to determine the action of saline purgatives. Many of the results have been separately published in various scientific journals, and they are now gathered together with certain new material in an attempt to give as connected and complete an account as possible of the action of this class of drugs.

The experiments were begun at the suggestion of Professor Loeb, to whom I am greatly indebted for the constant interest which he has taken in the work, and whom it is a pleasure to thank for many helpful suggestions.