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The Toxicity of Caffein: An experimental study on different species of animals

Chapter 30: FOOTNOTES:
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About This Book

The study reports controlled laboratory experiments that measure physiological effects, toxicity, and lethal responses to caffein in multiple mammalian species. After a historical review it presents acute and chronic exposure trials, with detailed protocols for oral, subcutaneous, intraperitoneal, intramuscular, and intravenous administration. Separate sections document clinical observations, autopsy findings, and dose-response differences in rabbits, guinea pigs, cats, and dogs. Results are analyzed in light of comparative metabolism, and the report concludes with a discussion and concise summary of interspecies variation in sensitivity and elimination of the alkaloid.

FOOTNOTES:

[A] The small figures refer to the bibliography at the end of this bulletin.

[B] Survived first dose.

[C] Time of injection inadvertently omitted, but was probably not slower than in the other cases of this series.

[D] Cat probably old; had been in the laboratory for several weeks before the experiment. Gained in weight 175 grams.

[E] A case of accidental poisoning reported recently by Wichura (Münich. Med. Woch., 1911, No. 30, p. 1618) throws some doubt on the accepted view that the susceptibility of young children to morphin is greater than that of adults. Wichura also found that the therapeutic doses of codein preparations ordinarily recommended for children in pleuritic cough are not effective in this condition.

Transcriber's Notes

Obvious typographical errors have been corrected, but variations in spelling, punctuation and hyphenation have been retained.

Rabbit 396. The date August 15 has been corrected to August 19.

The data for Rabbit 123 is presented as printed in the original, although it is likely that the Caffein per kilo. values should be preceded by a decimal point (or that the heading should be Mg.).

Standard footnotes are identied alphabetically. Numeric references within the text refer to the bibliography.

The headings of Table 18 have been abbreviated for clarity on small screens.