The author investigates why many people die before old age and argues that much premature physical and mental decline is preventable. He describes arteriosclerosis—its pathology, causes, and links to lifestyle—and presents practical guidance on prevention through diet, exercise, hygiene, and physician–patient cooperation. The work is organized into chapters on choices of living, the nature and causes of arterial hardening, methods of safeguarding health, and medicinal approaches to sclerosis. Throughout, the tone critiques medical pretension while stressing personal responsibility, careful observation of symptoms, and pragmatic measures to prolong a healthy life.