An Inquiry into the Cause and Effects of the Variolæ Vaccinæ, a Disease discovered in some of the Western Counties of England, particularly Gloucestershire, and known by the name of the Cow Pox. London: 1798.

1798.—What renders the Cow Pox Virus so extremely singular is, that the person who has been thus affected is for ever after secure from the infection of the Small Pox; neither the exposure to the variolous effluvia, nor the insertion of the matter into the skin, producing this distemper.

It is curious to observe, that the virus, which with respect to its effects is undetermined and uncertain previously to its passing from the horse through the medium of the cow, should then not only become more active, but should invariably and completely possess those specific properties which induce in the human constitution symptoms similar to those of the variolous fever, and effect in it that peculiar change which for ever renders it unsusceptible of the variolous contagion.

It clearly appears that this disease leaves the constitution in a state of perfect security from the infection of the Small Pox.—Pp. 121, 337.

Further Observations on the Variolæ Vaccinæ. London: 1799.

1799.—The result of all my trials with the virus on the human subject has been uniform. In every instance the patient who has felt its influence has completely lost the susceptibility for the variolous contagion.—Pp. 152-158, 336.

A Continuation of Facts and Observations relative to the Variolæ Vaccinæ, or Cow Pox. London: 1800.

1800.—The scepticism that appeared even among the most enlightened of medical men, when my sentiments on the important subject of the Cow Pox were first promulgated, was highly laudable. To have admitted the truth of a doctrine, at once so novel and so unlike anything that had ever appeared in the Annals of Medicine, without the test of the most rigid scrutiny, would have bordered upon temerity; but now, when that scrutiny has taken place, not only among ourselves, but in the first professional circles in Europe, and when it has been uniformly found in such abundant instances, that the human frame, when once it has felt the influence of the genuine Cow Pox in the way that has been described, is never afterwards, at any period of its existence, assailable by the Small Pox, may I not with perfect confidence congratulate my country and society at large on their beholding in the mild form of the Cow Pox, an antidote that is capable of extirpating from the earth a disease which is every hour devouring its victims; a disease that has ever been considered as the severest scourge of the human race.—Pp. 166, 338-339, 357, 365, 473.

The Origin of Vaccine Inoculation. London: 1801.

1801.—It now becomes too manifest to admit of controversy, that the annihilation of the Small Pox, the most dreadful scourge of the human species, must be the final result of this practice.—P. 183.

Petition for Remuneration to House of Commons. 1802.

1802.—Cow Pox admits of being inoculated on the human frame with the most perfect ease and safety, and is attended with the singularly beneficial effect of rendering through life the persons so inoculated perfectly secure from the infection of the Small Pox.—Pp. 184, 337, 355.

On the Varieties and Modifications of the Vaccine Pustule occasioned by an Herpetic State of the Skin. Printed in Medical and Physical Journal, August, 1804; and reprinted as a pamphlet, Cheltenham, 1806, and Gloucester, 1819.—P. 340.

VACCINATION EQUAL TO VARIOLATION.

1804.—What I have said on Vaccination is true. If properly conducted it secures the constitution as much as Variolous Inoculation possibly can.—Baron’s Life of Jenner, vol. ii. p. 15.

Duly and efficiently performed, Vaccination will protect the constitution from subsequent attacks of Small Pox as much as that disease itself will. I never expected that it would do more, and it will not, I believe, do less.—Ibid. p. 135.

1806.—The security given to the constitution by Vaccine Inoculation is exactly equal to that given by the Variolous. To expect more from it would be wrong. As failures in the latter are constantly presenting themselves, we must expect to find them in the former also.—Letter to Richard Dunning, 1st March, 1806.—Pp. 339, 355.

Facts for the most part unobserved or not duly noticed respecting Variolous Contagion. London: 1808.

1808.—It should be remembered that the constitution cannot, by previous infection, be rendered totally insusceptible of the Variolous Poison. Neither the casual, nor the inoculated Small Pox, whether it produce the disease in a mild or violent way, can perfectly extinguish the susceptibility.—P. 338.

Letter to William Dillwyn on the Effects of Vaccination in Preserving from the Small Pox. Philadelphia: 1818.

1818.—My confidence in the efficacy of Vaccination to guard the constitution from Small Pox is not in the least diminished. That exceptions to the rule have appeared, and that they will appear, I am ready to admit. They have happened after Small Pox Inoculation; and by the same rule, as the two diseases are so similar, they will also happen after Vaccine Inoculation.—P. 344.

Last Testimony.

1823.—My opinion of Vaccination is precisely as it was when I first promulgated the discovery. It is not in the least strengthened by any event that has happened, for it could gain no strength; it is not in the least weakened; for if the failures you speak of had not happened, the truth of my assertions respecting those coincidences which occasioned them would not have been made out.—P. 354.

The whole of Jenner’s claims re-asserted for Smallpox Cowpox by Mr. John Simon, after Inoculation with which—

1857.—“Neither renewed vaccination, nor inoculation with Smallpox, nor the closest contact and cohabitation with smallpox patients, will occasion him to betray any remnant of susceptibility to infection.”—Papers relating to the History and Practice of Vaccination. London: 1857.—P. 513.

Jenner’s Successive Poxes

In their order, 124, 185, 207, 240, 334-338, 347-348, 472-473, 512-513.
Cowpox, first faith, 93-95, 99, 114, 334.
Swinepox, 98, 99, 262.
Cowpox did not prevent smallpox, 99, 113, 143, 179, 201, 347, 512.
Horsegrease, 97, 99-100, 104, 124, 142, 273, 335.
Spurious Cowpox defined, 99, 113-114.
Horsegrease Cowpox, 100, 110-114, 119-121, 124-125, 153-155, 198, 201, 259-274, 335, 375.
Horsegrease dropped, 178-180, 201-203, 260, 266, 375.
Cowpox resumed, 180-183, 202-203, 512.
Spurious Cowpox dropped, 239-240, 277-278, 314, 336, 356, 454.
Horsegrease or Horsepox adopted neat, 229, 264-273;
the true and genuine life-preserving fluid, 269;
equine virus sent to Edinburgh, 368.
Sacco’s practice, 264, 267, 336, 512,
and De Carro’s, 265, 405.

LETTERS FROM JENNER TO—

John Addington, Surgeon.
1802.—Detained at Berkeley by domestic joys, 218
1804.—Cannot leave his wife, 222

John Baron, M.D.
1810.—Denunciation of Brown of Musselburgh, 351
1811.—London and the Grosvenor disaster, 319
1818.—The true and genuine life preserving fluid from a horse, 269
”   —Vaccination equivalent to smallpox, 355

Miss Calcraft.
1811.—Apology for Grosvenor disaster, 320

Dr. De Carro, Vienna.
1803.—Opposition to horsegrease hindered vaccination, 265
”   —Transmission of virus to India, 385

W. Dillwyn, Walthamstow.
1818.—Difficulties which attend vaccination, 341-345

Richard Dunning, Surgeon, Plymouth.
1804.—Terms Vaccinate and Vaccination, 229
”   —Herpes the pest of vaccination, 340
”   —John Ring and Goldson, 351
”   —Despotism in India, 385
1804.—England compared with India, 389
1805.—Potatoes, 89
1806.—Vaccination equal to variolation, 339
”   —Wicked opposition in London, 361
1807.—Odd notion about Hindoo women, 390
”   —Vaccination in Chinese, 394

Dr. Fleming, Calcutta.
1806.—Vaccination and variolation in England, 390

A Friend.
1794.—Origin of cowpox in horsegrease beyond denial, 100
1797.—Difficulty of raising cowpox from horsegrease, 100
1804.—Experience as London physician, 216-217

Edward Gardner.
1796.—First arm to arm vaccination, 101
1798.—True and false cowpox, 99
”   —Perplexity and agitation, 129
”   —Conceit and ignorance of Ingenhousz, 131
1798.—Brickbats flying around, 135
1799.—Counteract Pearson, 147
”   —Extreme pains with Further Observations, 152
1823.—Homicidal Edinburgh Review, 364

Dr. Ingenhousz.
1798.—Prophylaxy of cowpox certain and permanent, 131

Andrew Johnstone.
1813.—Declines to preside over United London Vaccine Institution and Royal Jennerian Society, 323

Dr. Lettsom.
1811.—Perversity of London: comfort in Asia and America, 321

James Moore.
1808.—Family afflictions, 255
1809.—Sir Lucas Pepys, 255
”   —Expected astonishment, 256
”   —Views and wrongs, 257
1810.—Impudence of John Gale Jones, 301
1812.—Vaccination in Prussia, 405
1813.—Fresh evidence of cowpox from horsegrease, 267
”   —Has been equinating for months, 267
”   —Experience with horsegreased carters, 268
”   —Proper variety of equine virus, 270
”   —Watt’s mischievous discovery, 451
1816.—Cowpox likely to cease through disappearance of horsegrease, 269
”   —Bad virus of National Vaccine Establishment, 458

Dr. George Pearson.
1798.—Cowpox follows cowpox, 142
”   —Vaccination always erysipelatous, 143
1799.—Refusal to join Vaccine Pock Institution, 161

John Ring, Surgeon.
1801.—Ignorance of time for taking virus, 181

W. F. Shrapnell.
1794.—Typhus at Berkeley, 85
1800.—Success in London, 171
”   —Praise of John Ring, 173

Dr. William Woodville.
1799.—Success with Woodville’s London virus, 149

Rev. Dr. Worthington.
1810.—Away with Malthus!, 89
”   —While variolation is practised smallpox cannot be subdued, 72, 390

LETTERS TO JENNER FROM—

John Addington, Surgeon.
1802.—Royal Jennerian Society, 218

Henry Cline, Surgeon.
1798.—Experiments, with cowpox, 128

Dr. Erasmus Darwin.
1802.—Christening and vaccination united, 276

Dr. De Carro, Vienna.
1803.—Horsegrease Jenner’s distinction, 405

Joseph Fox.
1802.—Royal Jennerian Society, 218

Dr. Hicks, Bristol.
1798.—Cowpox from horsegrease, 133

Lord Holland.
1803.—Vaccination in Spain, 400

John Hunter.
”  —Puffing Jenner’s tartar emetic, 93

Dr. Ingenhousz.
1798.—Adverse inquiries as to cowpox, 130

Thomas Jefferson.
1806.—Glorifies vaccination, 380

Rev. G. C. Jenner.
1799.—Excites jealousy of Pearson, 147

Francis Knight, Surgeon.
1798.—Attests country faith in cowpox, 132

Dr. Marshall.
1801.—Vaccination in Naples, 398

Dr. George Pearson.
1798.—Associates himself with Jenner and reports public dislike of horsegrease, 134
1799.—Invitation to join Vaccine Pock Institution, 160

Dr. Percival, Manchester.
1798.—Failure to get cowpox from horsegrease, 133

Dr. Sacco, Milan.
1808.—Miraculous exploits as vaccinator, 403

Lord Sherborne.
1801.—Advice as to petition for reward, 184

Benjamin Travers.
1803.—Royal Jennerian Society, 219

Dr. Underwood, Madras.
1801.—Dread of variolation, 383

Dr. Benjamin Waterhouse.
1801.—Vaccination accounted beastly and indelicate in Philadelphia, 374
”   —Dexterous management of vaccination, 377
”   —Vaccinates cows, 378
”   —Cows with smallpox, 379