Qualities. Form, tortuous pieces of the thickness of a goose-quill, surrounded by numerous prominent rings, separated by deep grooves. This root, when powdered, has a faint disagreeable odour, and a bitter sub-acrid taste. Chemical Composition. The late researches of M. M. Majendie and Pelletier have detected the existence of a new vegetable proximate principle in this root, to which ipecacuan is indebted for its emetic properties; they have, accordingly, denominated it Emetine.^[543] It assumes the form of transparent brownish red scales, which are nearly inodorous, but have a slightly bitter, acrid, but not nauseous taste. Emetine is decomposed by a heat higher than that of boiling water; it is insoluble in water, in every proportion, without undergoing the least change; and in a moist atmosphere it deliquesces; it is also soluble in alcohol, but not in æther; nitric acid dissolves it, but at the same time decomposes it; dilute sulphuric acid has no action on it; muriatic acid and phosphoric acid dissolve it, without altering its nature; acetic acid dissolves it with great facility; corrosive sublimate precipitates it from its solutions, but tartarized antimony has no effect upon them; gallic acid, the infusion of galls, and acetate of lead, precipitate it. A grain excites violent vomiting, followed by sleep, and the patient awakes in perfect health! It exerts also a specific action on the lungs and mucous membrane of the intestinal canal; when taken in an overdose, its action can be instantly paralysed by a decoction of galls. There seems to be no great advantage in substituting this body for the ordinary powder of Ipecacuanha, except perhaps that its taste being much less offensive, it may very easily be given to children.^[544] Emetine appears to exist in Ipecacuanha, combined in the following manner, emetine 16, oils 2, wax 6, gum 10, starch 40, woody fibre 20.

Since the discovery of Emetine, whose properties are described above, Pelletier has extended his researches into its composition and nature; and he has lately been enabled to state that this body, which in conjunction with Majendie, he had formerly announced as “a new vegetable proximate principle,” turns out to be a compound of a peculiar alkaline basis, which may be called Emeta, and some acid, together with an admixture of colouring matter; when compared with Emetine, it is what white crystallized sugar is to moist sugar. Its ultimate elements are oxygen, hydrogen and carbon; it is a white and friable substance, and unlike Emetin, is not altered by exposure to air; it is slightly bitter, and very sparingly soluble in water; with the mineral acids it forms salts, from whose solutions the infusion of galls throws down white and flocculent precipitates; the alcoholic solution of Emeta acts upon vegetable colour as an alkali.

Medicinal Uses of Ipecacuan. It is unquestionably the most valuable of the vegetable emetics, and in cases where the stomach is irritable it is to be preferred to Tartarized Antimony, and it is also less liable to act upon the bowels. In the form of decoction (made by boiling three drachms of the bruised root in a quart of water down to a pint) it has been found serviceable as an enema in Dysentery, and internal piles. Incompatible Substances. All vegetable astringents, as infusion of galls, &c. vegetable acids, especially the acetic, weaken its power; Dr. Irvine found that grs. xxx, administered in f℥ij of vinegar, produced only some loose stools. Forms of Exhibition. The form of powder is most energetic, although the vinous solution is both active and convenient. Dose. The medicinal operation of this substance varies with its dose, thus grs. x to ʒss act as an emetic; (Form: 65,) grs. j to ij, as an expectorant, (Form: 134, 138,)and in still smaller doses it proves stomachic and diaphoretic; by combination with opium, this latter quality becomes more powerful, (Form: 28, 130.) The primary effect of this medicine is that of stimulating the stomach, and it is equally obvious that its secondary ones depend on the numerous sympathies of other parts with the organs of digestion. The action of this remedy upon the pulmonary organs is extremely interesting; it would seem that in certain conditions of these organs, attended with a dry, hard cough, it promotes expectoration, while in affections attended with an inordinate secretion of mucus, it as certainly represses it, and acts the part of an astringent. In dysentery, and chronic diarrhœa, its astringent power is also very decided. Form: 58. When combined with cathartics it aids and accelerates their operation; Form: 84. In Hemorrhage from the lungs and uterus, it is decidedly useful, when administered in such doses as to excite a slight degree of nausea, by which the force of the circulation is controlled; I have usually combined it, for such a purpose, with the Acetate of lead in Hæmopthysis; and Bergius relates a case of violent uterine hæmorrhage which was successfully treated by giving half a grain every half hour. In certain forms of Dyspepsia it proves highly beneficial, when administered as proposed by Daubenton, in doses just sufficient to excite a slight sensation of vermicular motion of the stomach, without carrying it to the point of nausea, which may be generally effected by half a grain three times a day. Its peculiar nauseous taste is completely covered by the addition of powdered Gum Arabic. Solubility. Alcohol takes up four parts in twenty of Ipecacuan; proof spirit six and a half; and boiling water rather more than eight parts; one pint of good sherry wine will dissolve about 100 grains; the alcoholic is more emetic than the aqueous solution; decoction destroys the emetic property of the root. Officinal Prep. Pulvis Ipecacuanhæ comp: L.E.D. Vinum Ipecac. L.E.D.^[545] The powder is liable to become inert by exposure to air and light. The root is refractory, and is reduced to powder with difficulty, unless a few drops of oil, or an almond or two, be previously added. It is a curious fact that the effluvia of this root occasion in some persons the most distressing sensations of suffocation. I am acquainted with a lady, who is constantly seized with a violent dyspnœa, whenever the powder of Ipecacuan is brought into her presence. Adulterations. There are several varieties of Ipecacuan to be found in the market, which it is important to distinguish; viz. 1, The brown variety, which is the best, containing sixteen per cent. of emetin; 2, the grey variety, with fourteen per cent. of emetin; 3, the white variety, with only five of emetin. The two former varieties are those usually met with, being imported into this country in bales from Rio Janeiro; the brown is distinguished from the grey, in being more wrinkled; the white variety has no wrinkles whatever. We are informed by Decandolle that the genuine root is frequently mixed with those of violets, Apocynæ, Euphorbia, &c. It is also sometimes mixed with the roots of several species of Ionidum.

Qualities. This root is pulverulent, furnishing a powder of a pale brownish yellow colour. Odour, peculiar; Taste, sweetish and slightly pungent. Chemical Composition. Resin, gum, extractive, fecula, lignin, and some salts. The combination of the three first principles appears requisite for the production of its full cathartic effect. The gum has been supposed to possess diuretic properties. Very lately a saline principle has been obtained from Jalap by Mr. Hume, jun.: but I am not aware that its medicinal properties have been ascertained. It is procured by macerating the powdered root for twelve or fourteen days in acetic acid, by which a solution is obtained, which must be filtered, and then saturated with ammonia; the mixture is to be shaken violently, when a sabulous deposit will take place, and a few crystals be collected on the sides of the vessel; both of these must be collected, and washed in distilled water; and then redissolved in concentrated acetic acid, and reprecipitated by ammonia added in excess. By which means, small white acicular crystals are thrown down, to which the name of Jalapine has been given. Solubility. Proof spirit is its appropriate menstruum. Med. Uses. It is a cathartic of a stimulating description, acting principally upon the colon, and, notwithstanding the tormina it may sometimes induce, it is no less safe than efficacious; as a hydragogue purgative it has been greatly extolled, but for such a purpose it will answer better in combination, as in Form. 73. Its action is said to be promoted by the addition of Ipecacuan, or tartarized antimony. (Form. 84.) In dropsy its union with super-tartrate of potass is calculated to promote its beneficial operation. Forms of Exhibition. That of powder is the most eligible, especially when combined with some other powdered substance: pulverization increases its activity, see Pulveres. Van Swieten advised it to be pulverised, and mixed with sugar, and a small quantity of some aromatic. The addition of Soap is supposed to render its operation much milder, and the Prussian Pharmacopœia contains a formula for such a combination, which is said to operate mildly and promptly. To this preparation the name Sapo Jalapinus^[546] is given. Dose, grs. x to ʒss. Officinal Preparations. Pulv. Jalap. comp. E. Extract. Jalap. L.E.D. Tinct. Jalap. L.E.D. Tinct. Sennæ comp. E. (B). Adulterations. Briony root is sometimes mixed with that of jalap, but it may be easily distinguished by its paler colour and less compact texture; and by not easily burning at the flame of a candle. When the teredo has attacked it, it should be rejected.

[The Butternut tree is to be found in almost every part of the United States. The inner bark is the part used in medicine. It yields, by analysis, a large quantity of soluble matter, principally of the extractive kind. Water extracts its virtues, and the Extract, which is the form in which it is employed, has long been known and used in this country as an excellent Cathartic. To obviate habitual costiveness, it is one of the best articles that can be used. By the addition of Calomel, its powers as an active Cathartic may be greatly increased. The proper season for gathering the bark for medicinal purposes is in the months of May and June. The dose of the Extract is from 10 to 30 grains.]

The principal constituents of these berries are mucilage, sugar, and volatile oil; in the latter of which their diuretic virtues reside. Forms of Exhibition. That of an infusion, made with ℥ij of the berries, to oj of hot water. Unless pains however are taken, by strong contusion, to bruise and break the seeds, the preparation will contain but little of the juniper flavour. The bruised berries may be also triturated with sugar or some neutral salt, and be thus exhibited in substance, Dose ℈j to ℈ij. Officinal Preparations. Oleum Junip. L.E.D. Spirit. Junip. Co. L.E.D. The taste and diuretic properties of Hollands depend upon this oil; English gin is flavoured by oil of turpentine.

There is very considerable obscurity with regard to the history and chemical constitution of this substance; three varieties of it are met with in the shops, viz. 1. African Kino, which bears the highest price, and has all the appearance of a natural production, slender twigs being often intermixed in its substance; it is of a reddish brown colour, and has a bitterish astringent taste. 2. Botany Bay Kino, has also the aspect of a natural production, it is in more solid masses than the former species, is less brittle (for it contains a very small proportion of resin) and, with its astringency, has a disagreeable sweetish taste. 3. Jamaica Kino, this is the one most commonly met with; it has the appearance of a dry extract, is in small fragments, of a colour more nearly approaching to black than that of the others, and has an astringent and slightly bitter taste. There is also a fourth variety mentioned, viz. the East India or Amboyna, but this does not appear to differ from the African variety. Chemical Composition. In all the varieties the predominant principles are tannin and extractive. Solubility. The best menstruum is diluted alcohol. Incompatible Substances, vide Gallæ. Mr. Thomson also states a fact which I have reason to consider quite correct, that the alkalies destroy the astringent properties of kino. All the varieties are soluble in solutions of pure potass and ammonia, and no precipitation takes place on the addition of water. Medicinal Uses. It is principally employed as an astringent, but from its liability to vary in strength, it has been very generally superseded by Catechu.^[548] Forms of Exhibition. Either in substance or in the form of watery infusion, or in that of tincture. Dose, grs. x to ʒss. Officinal Preparations. Tinct. Kino. L.E.D. Elect. Catechu. E.D. Pulvis Alum. co. E.

This root, although it has been for some time employed in medicine, has only lately found its way into the Materia Medica of the London Pharmacopœia. Its extract, which was some years ago imported into this country, is supposed to have been employed for giving astringency to Port wine. According to recent analysis the root contains a peculiar modification of Tannin, with only a trace of Gallic acid; Gum; Fecula; and certain salts of Lime. It may be used either in decoction, or tincture, the latter of which may be made by dissolving two ounces of the root in a pint of proof spirit. In all its forms it is eminently astringent. I have used it with much success in Leucorrhæa, and in uterine hemorrhages. The extract may be distinguished from Kino, to which it bears a great resemblance in appearance and taste, by being very fusible by heat, whereas Kino does not possess that character.

Qualities. Odour, none; Taste, mucilaginous and bitter. Solubility. The effect of water upon this vegetable substance is materially modified by temperature; if cold, the lichen absorbs nearly its own weight by maceration, but gives out to the menstruum little or none of its virtues; if the water be warm, it soon acquires a bitter impregnation; by ebullition, a decoction is obtained, which, as it cools, gelatinizes. See Decoct. Lichen. Chemical Composition. Proust has shewn by analysis that 100 parts of this moss contain 64 parts of a substance bearing some analogy to vegetable gluten, 33 of matter, soluble in hot water, and resembling starch, and 3 parts of a bitter principle. Medicinal Uses. This vegetable was introduced to the notice of the profession by Linnæus, who recommended its decoction, as having been administered with great success for coughs in Sweden. Upon its introduction into this country, its patrons bestowed so many extravagant eulogiums upon its powers, that the less sanguine practitioner at once abandoned its use in disgust, and it fell into unmerited disrepute. It would be idle to speak of its specific effects in phthisis; but, as a demulcent, it is certainly very superior to the mucilaginous mixtures in ordinary use, and its simple bitter principle at the same time tends to produce a tonic effect, which is frequently desirable in the debilitated condition which characterizes the latter stages of this disease. There are circumstances, however, which may render the removal of the bitter advantageous; in which case, maceration in successive waters, or in a weak alkaline ley, as recommended by Westring, will be found to answer the intended purpose. Officinal Preparation. Decoct. Lichen. Island. E. D. Sir Alexander Crichton has offered some observations upon the genuineness of this article which deserve attention. He says that there are two varieties in the market; the best of which has a horny texture, and yields a bitter mucilage. It is that which comes from Iceland, Norway, Sweden, and Finland. The inferior kind has a membranous texture, and yields little bitter or mucilage in comparison with the former. Where it comes from he knows not, but he suspects it to be British, as it is much cheaper than the other.

Succus—The Juice consists of Citric acid, mucilage, extractive matter, and small portions of sugar and water. Specific gravity, 1·0384. It may be preserved for a considerable length of time, by covering its surface with fixed oil.

Its use in making saline draughts has been already noticed, see Acid. Citric. Its principal medicinal value consists in its antiscorbutic^[549] virtues; indeed it may be fairly asserted that this disease, so peculiarly incident to a sea life, has been nearly eradicated by the juice of lemons. Sir Gilbert Blane, in speaking of its efficacy, asserts that “those only who have made themselves acquainted with the early part of the Naval history of this country, or those who have perused the interesting, popular, and eloquent narrative of Commodore Anson’s voyage, can duly appreciate the value of this simple remedy.” Lemonade, as a beverage in putrid diseases, was first introduced by the French physicians in the beginning of the 17th century, and about the year 1660, an Italian from Florence, having learnt a process of freezing confectionary, conceived the happy idea of converting such beverage into ice. This found a ready sale, and was the occasion of so great an increase in the number of sellers of Lemonade, that in the year 1676, the Lemonadiers of Paris were formed into a company, and received a patent from the government.

Cortex—The Rind or Peel is composed of two distinct parts; the exterior, which contains glands, filled with a fragrant volatile oil, upon which all its properties depend, and the interior coat, which is tasteless and indigestible. The flavour may be obtained by rubbing lump sugar upon it, which will imbibe the oil, and if it be then dried by a very gentle heat, may be preserved unimpaired for any length of time, and will be preferable to the volatile oil obtained by distillation, for the fire generally imparts an unpleasant or empyreumatic flavour.^[550]

It has been already stated, that “the different parts of the same plant have frequently very different properties.” The Lemon offers a good example of this fact, for its juice is acid, its seeds bitter, and its peel aromatic.

These are external applications, having the consistence of oil or balsam. If we except the Liniment. Æruginis, all the officinal liniments are decomposed by the substances which are incompatible with soaps.

Linimentum Æruginis. L. Oxymel Æruginis. P.L. 1787. Mel Ægyptiacum. P.L. 1745. Unguentum Ægyptiacum. P.L. 1720. Diluted with water, it has been recommended as a gargle in venereal ulcerations, but its use is hazardous; it is a detergent escharotic preparation.

Linimentum Ammoniæ Fortius. L. Oleum Ammoniatum. E. Linimentum Ammoniæ. D. It consists of liquor ammoniæ one part, olive oil two parts, (oil eight parts, E.D.) The alkali forms with the oil a soap, which is held dissolved by the water in the liquor ammoniæ. Is an excellent rubefacient, and penetrating liniment.

Linimentum Ammoniæ Sub-carbonatis. L. Linimentum Ammoniæ. P.L. 1787. Linimentum Volatile. P.L. 1745. The carbonic acid prevents the perfect formation of soap in this liniment; unlike the former one, therefore, it deposits the soapy matter on standing. It is much less stimulating than the preceding one.

Linimentum Calcis. E.D. Oil and lime water, equal parts. This is an earthy soap, formed by the combination of lime and oil; the soapy matter separates on standing, it should therefore be extemporaneous. In cases of burns and scalds where the cuticle has been destroyed, it is an advantageous application.

Linimentum Camphoræ. L. Oleum Camphoratum. E.D. Camphor one, olive oil four parts. It is a simple solution of camphor in fixed oil, and forms a very useful embrocation to sprains, bruises, glandular swellings, and in rheumatic affections.

Linimentum Camphoræ compositum. L. Camphor two, liquor ammoniæ six, spirits of lavender sixteen parts. It is highly stimulating.^[551]

Linimentum Hydrargyri. L. A pound of this liniment contains nearly ℥iv of mercury; it affects the mouth more rapidly than strong mercurial ointment, although it will be seen by the Medicinal Dynameter to contain less Mercury. This effect is to be attributed to the stimulating properties of its adjuncts, viz. Camphor and Ammonia.

Linimentum Saponis compositum. L. Hard soap iij, camphor j, spirit of rosemary xvj parts. It is a stimulant and anodyne application, and in local pains opium may be advantageously added to it. It is commonly used under the name of Opodeldoc.^[552] See Sapo.

Linimentum Terebinthinæ. This liniment was introduced by Mr. Kentish of Newcastle, as a dressing to recent burns, which he continued until the eschars became loose.

The qualities of this plant reside in extractive matter, hence water extracts, but long decoction injures them. Medicinal Uses. It is strongly purgative. Forms of Exhibition. ʒij of the dried herb infused in oj of boiling water. Dose, f℥ij.

These seeds contain a large proportion of mucilage, and one-sixth of their weight of fixed oil; the former of which resides principally in the cuticle, the latter, in the parenchymatous portion of the seed; by infusion in boiling water, a clear, colourless, inodorous, and nearly insipid mucilage is obtained; ℥ss of the unbruised seed is sufficient for oj of water; cold water does not extract any mucilage from them when unbruised; the farina of the seeds is well adapted for cataplasms. Officinal Prep. Infus. Lini Comp: L. Oleum Lini. L. E. D.

This is a compound solution of alum and sulphate of zinc; a fluid-ounce containing about seven grains of each ingredient, it is powerfully astringent, and is successfully used as a detergent lotion to old ulcers; as a collyrium, or as an injection in gleet and fluor albus; it will also often answer in removing chilblains, and in curing slight excoriations.

Qualities. Form, a limpid, colourless fluid; specific gravity, ·960, or f℥j weighs about 438 grs. Odour, strong and pungent; Taste, extremely caustic. Chemical Composition. A solution of ammoniacal gas in water, which varies considerably in strength in the different pharmacopœias. When prepared according to the London and Edinburgh Colleges, it contains nearly 25 per cent. of ammonia, whereas the Dublin preparation does not contain more than 16. Solvent Powers. It is an active solvent of many vegetable principles, e. g. oils, resins, &c. With alcohol it unites in every proportion; it assists the oxidizement of copper and zinc, and dissolves many of the metallic oxides. Med. Uses. Stimulant, rubefacient, and antacid. Forms of Exhibition. In milk, or any liquid vehicle; if in decoctions, or infusions, they must be previously cooled; for at 130° the ammonia will escape in the form of gas. Dose, ♏︎x to xxx. Officinal Prep. Linimentum Ammoniæ. L.D. Oleum Ammon. E. Spir. Ammoniæ. L. Spir. Ammoniæ comp. L. Spir. Ammon. succinat. L. Liniment. Camphor. comp. L. Adulterations. The presence of other salts in the solution may be discovered by saturating a portion with pure nitric acid, and applying the test for sulphuric acid, (Barytes) and that for muriatic acid, (Nitrate of Silver.) Carbonic acid is detected by its effervescing with acids, or by its forming with lime water, a precipitate, soluble with effervescence in nitric acid; it ought to be free from all fetor; its strength can only be determined by taking its specific gravity. It should be preserved in well closed bottles, and their dimensions should be small, for when in large vessels it often becomes carbonated before it is half used.

This preparation is a solution of the neutral acetate of ammonia, with a proportion of carbonic acid diffused through it; it is made by saturating the sub-carbonate of ammonia with distilled vinegar, for which purpose it will generally be found that ℥j of the alkali will saturate oiss of the vinegar; since, however, the quantity of acid in distilled vinegar as well the strength of the ammonia, are liable to constant variation, the exact point of neutralization should be ascertained by the alternate application of litmus and turmeric papers; for if the proportions be not accurately adjusted, some of the metallic salts, especially those of antimony, which are often prescribed in conjunction with it, are decomposed, and thus rendered inefficacious; and on this account an excess of alkali is to be feared more than that of acid. This preparation is also not unfrequently employed as a collyrium, when much serious mischief may arise from the carbonate of ammonia predominating. It has been already stated that a very minute proportion of extractive matter is rendered sensible on the addition of an alkali; hence this preparation frequently derives from the vinegar a brown hue, which may be removed by filtering the solution through a little well burnt charcoal. It also deserves notice that the presence of a trace of copper, derived from the copper cocks through which the vinegar has passed, will impart a brown tinge, whilst in larger quantities this metal yields a blue colour with ammonia. Incompatible Substances. Acids; fixed alkalies; alum; lime water; sulphate of magnesia; corrosive sublimate; nitrate of silver; and the sulphates of zinc, copper, and iron. Acetate of lead produces also a copious precipitation, but this depends upon the presence of the carbonic acid diffused through the solution, which decomposes the salt and forms an insoluble carbonate of lead. Magnesia likewise, contrary to what might be supposed, decomposes the solution and renders it pungent, from the extrication of ammoniacal gas; this phenomenon depends upon the magnesia forming a triple acetate with one part of the ammonia, and setting the remainder at liberty. Med. Uses. When assisted by warmth and plentiful dilution, it is an excellent diaphoretic, and produces its effects without quickening the circulation: (Form: 117, 126,) by keeping the surface of the body cool, its action is determined to the kidneys, and it proves diuretic, especially when combined with remedies of a similar tendency. (Form: 111.) Dose, fʒiv to fʒxij. Externally it furnishes a lotion, valuable as a refrigerant, especially when combined with some spirituous preparation. See Form: 148.

This is merely a solution of the solid sub-carbonate in distilled water, see Ammoniæ Sub-carbonas. Dose, fʒss to fʒj in any bland liquid. Adulterations. There is frequently a deficient quantity of the sub-carbonate in solution, its pungency being kept up by the addition of liquor ammoniæ; this may be discovered by shaking it with twice its bulk of alcohol, when a coagulum of considerable density should occur, the absence of which will denote the sophistication of the article. Its specific gravity should be 1·150. The Incompatibles are those enumerated under the history of Ammoniæ Sub-carbonas.

This is a solution of the Arsenite of Potass, coloured and flavoured by the Compound Spirit of Lavender, fʒj of which contains gr. ½ of arsenious acid. It was introduced into practice by Dr. Fowler of Stafford, as a substitute for the empirical remedy known by the name of “The Tasteless Ague Drop.” It is a powerful tonic, and has been very successfully administered in the cure of intermittent and remittent fevers, periodical headaches, and as an alterative in many anomalous diseases of the skin. It has been also given, with decided effect, in certain visceral obstructions; its use however is to a great degree empirical, although we may observe, generally, that wherever strong arterial action exists, arsenic will do harm. The addition of a few drops of Vinum Opii is said to render its operation safer and more efficacious. Incompatible Substances. Lime water; nitrate of silver; the salts of copper; hydro-sulphuret of potass, and the infusions and decoctions of bark. Dose, ♏︎iv, gradually increased to ♏︎xxx, twice a day. See Arsenicum Album.

It is a saturated solution of lime in water; f℥j of which contains 3/4 of a grain.^[553] Incompatible Substances. All alkaline and metallic salts; borates; tartrates; citrates; acids; sulphur; spirituous preparations, and the infusions of all astringent vegetables. It should be kept in close vessels, for if exposed to the air, the lime will attract carbonic acid, and become an insoluble carbonate; the addition of an alkaline carbonate produces the same effect instantaneously.^[554] If animal charcoal be boiled with lime-water, it will precipitate the whole of the lime, an effect which is not produced by charcoal of vegetable origin. Med. Uses. It is an antacid, and is therefore useful in dyspepsia attended with acidity; Form. 149. Mixed with an equal quantity of milk, it furnishes an excellent remedy in infantile complaints connected with bowel affections; it is likewise astringent in leucorrhæa, in the last stages of dysentery, and in protracted diarrhœa. It dissolves also the slimy mucus with which disordered bowels are so generally infested; on account of this latter property, it has been exhibited in calculous affections,^[555] with the view of dissolving the cementing ingredient of the concretion, and thereby of destroying its cohesion: see page 123. Not being very nauseous, it is easily given under any circumstances, and it is not liable to produce that irritability of stomach which frequently attends the long continued use of the fixed alkalies. It also frequently forms the basis of astringent gargles. Lime water moreover affords a successful remedy in certain cutaneous affections, particularly those affecting the face, as Gutta Rosea. Sir G. Blane has also seen some remarkable cures of herpetic complaints of the legs by large doses; he has also employed it with effect as a lotion. Forms of Exhibition. Milk disguises its flavour, without impairing its virtues. Dose, f℥j to f℥vj. Sugar has the curious property of rendering lime more soluble in water. See Saccharum.

This solution is said to be tonic and deobstruent, and to have been advantageously given in scrofula. It has also been found useful in Urticaria, and several other forms of cutaneous disease. Incompatibles. Sulphuric acid, and the Sulphates; the fixed alkalies and their carbonates; ammonia produces no change in the solution, but its carbonate decomposes it, and precipitates carbonate of lime. Dose, ♏︎xx to fʒij.

This is a simple solution of the salt in distilled water. The preparation, although perfectly transparent when first formed, soon becomes turbid and deposits oxide of copper; this arises from the escape of ammonia, and may be prevented by the occasional addition of a small quantity of the volatile alkali. See Cuprum Ammoniatum. The Medicinal Dynameter will show the proportion of salt in any given quantity of the solution.

This preparation is nearly the same as Stahl’s Tinctura Martis Alkalina. Chemical Composition. It is by no means ascertained. Incompatible Substances. It is a most injudicious preparation, for it cannot be exhibited in any form without decomposition; water, especially if not distilled, and vegetable infusions and decoctions, produce dense precipitates; pure acids, alkalies, and spirit, also decompose it. I must confess my regret at the College having retained this preparation in their Pharmacopœia; the committee agreed to reject it, but their judgment was reversed by the votes of the Comitia Majora. Should any practitioner be unable to procure this preparation, I will give him an easy receipt for producing it, viz. Let him keep the Mistura Ferri composita in an open vessel, until it is entirely spoilt!

This solution of corrosive sublimate is intended to facilitate the exhibition of minute doses of the salt; f℥j contains gr. ½; when long kept, or exposed to light, the oxy-muriate is decomposed, and calomel is precipitated; (see Hydrag: Oxymuriatis:) or, what is more dangerous, it is sometimes deposited in crystals, without decomposition; a small portion of muriatic acid, or muriate of ammonia in the solution, prevents this precipitation. Dose, fʒss to fʒij, in an infusion of linseed.

This preparation was introduced by M. Goulard of Montpellier, hence it has been commonly known by the name of Goulard’s Extract. Qualities. It is of a greenish straw colour, and has an austere, sweetish taste; when kept it deposits a quantity of oxide, and becomes lighter coloured. Chemical Composition. It is a saturated solution of the sub-acetate of lead, consisting, according to Berzelius, of one proportional of acid, and three proportionals of oxide of lead; hence its name is correct. It is the only instance with which we are acquainted of a real sub-salt being soluble in water. Incompatible Substances. Alkalies and their carbonates precipitate a white sub-salt; alkaline sulphates and sulphurets; mucilage. Spring Water, from the salts which it contains, produces with it a very milky and turbid appearance; and even when distilled, in consequence of the carbonic acid diffused through it, it occasions precipitation. The Surgeon will remember that the Linimentum Saponis cannot be mixed with it, without mutual decomposition. See Sapo. Med. Uses. It is only used externally, in superficial and phlegmonic inflammations of the skin, and in herpetic affections. It has been a question whether Lead, in any form, should ever be applied to an open wound, or to an abraded surface;^[556] as a general rule, it should not certainly be applied to such as are recent, nor to those whose character indicates a diminished state of vitality in the parts, and exhibits a disposition to gangrene. The abuse of Saturnine lotions has been frequently descanted upon by foreign writers, and, among the evils which are supposed to be thus induced, impotence is mentioned as one of not unfrequent occurrence. See Institutioni di Medicina Forens: di Tortosa, vol. 1. p. 58. also Fritze Compend: sopra le Malat: Vener: p. 189. and Monteggia Annotat: sopra i Mali Venerei, p. 36. There is a paper in the third volume of the Medical Transactions, by Dr. Reynolds, in which the case of a gentleman is detailed, who brought on a temporary paralysis of the Sphincter Ani, by freely using Goulard’s lotion for the cure of the Piles. The value of Saturnine applications in common inflammation most probably arises from a partial paralysis of the nerves of the part, produced by the sedative agency of the lead.

Qualities. A limpid, dense, colourless solution; a pint should weigh ℥xvj; when rubbed between the fingers it feels soapy, in consequence of a partial solution of the cuticle. The solution, as usually prepared, contains small portions of muriate and sulphate of potass, silica and lime; but these incidental impurities do not invalidate its virtues; it ought not to effervesce with acids. Med. Uses. Antacid, diuretic, alterative, and lithonthryptic; and externally, when diluted, it acts as a stimulating lotion,^[557] and if concentrated, as a caustic; see Potassa Fusa. The operation of this and other alkaline remedies, have at different periods been celebrated as powerful lithonthriptics, and whilst experience has in some cases confirmed the value of the practice, it has in others proved no less decidedly its mischievous agency; these contradictory results are at length capable of explanation, for Chemistry has drawn aside the veil that has so long obscured the history, origin, and cure of calculous diseases, and has demonstrated that these extraneous bodies vary in composition, and are consequently very differently affected by the same chemical solvents; but this subject has already been so fully discussed in the first part of this work, under the chapter on “Antilithics and Lithonthryptics,” that it is unnecessary to dwell upon it in this place.

It has also been found highly useful in the cure of several species of cutaneous affections; as in Lepra, Psoriasis, &c. which diseases generally appear to have some connection with a morbid state of the digestive functions; see Form: 149. Dose of the solution of potass, ♏︎x to fʒss, in veal broth^[558] or table beer; this latter vehicle disguises its nauseous flavour completely. In many cases, the infusion of some bitter tonic will be the most eligible liquor in which it can be exhibited, especially where our object is to promote its absorption: the theory of such a combination has been already explained in the first part of this work, p. 153. Officinal Prep. Potassa fusa, L.E.D. Potassa cum calce, L.E.D. Liquor Sulphureti Kali, D. Antimonii Sulphuretum Præcipitatum, L.E.