In 1490 Niccolò degl’Antinori bought this palace from the Boni della Catena. It is supposed by some to have been built by Baccio d’Agnolo, whilst others think that Giuliano da San Gallo was the architect on account of some resemblance with Palazzo Gondi.

The origin of the Antinori is as uncertain as that of their palace, but they are probably an offshoot of the powerful family of Buondelmonti. Francesco degl’Antinori was the first of twenty-three Priors of his house in 1351. His eldest great-nephew, Niccolò, bought the Boni palace, while the second, Bernardo, was the founder of another branch of the family whose palace is in Via de’ Serragli. Niccolò was four times elected a Prior, in 1498 he was Captain of Arezzo, three years later he was sent to quell a revolt at Pistoja, and then he was named ambassador at Milan. His sons took opposite sides in politics; the two eldest, ardent republicans, were banished when the Medici returned to Florence in 1513, whilst the third, Alessandro, was created a Senator by the Duke Alessandro. A like honour fell to his son Sebastiano who was selected by Cosimo I. to revise Boccaccio’s writings. Alessandro’s other son Lorenzo was a great traveller, a good musician and an excellent man of business who augmented the family wealth, and his descendants filled many important posts under the Grand Dukes of Tuscany.19 This fine palace still belongs to the Antinori family.