Ottaviano de’ Medici, whose house adjoined the Orti Medicei, bought, in order to obtain an exit into Via San Gallo, a house, courtyard and loggia, from the Compagnia dei Tessitori di Drappi, an offset of the Guild of Silk. The beautiful loggia in Via San Gallo, which Signor Iodico del Badia attributes to Giuliano da San Gallo, was walled up, but has recently been opened and well restored.23 Ottaviano was held in such high esteem by the Medici family that Clement VII. made him administrator of all their property in Tuscany, and guardian of the young Duchess Caterina, the orphan daughter of Lorenzo, Duke of Urbino, who afterwards became Queen of France. When Ippolito and Alessandro de’ Medici were forced to fly the city in 1527, Ottaviano took up his abode in the great Medici palace, in order to protect it from being looted. With the accession of Alessandro his duties ceased as far as the palace and the villas were concerned, but it was only when Cosimo I. ascended the throne that he was called upon to hand over the vast territorial possessions. He was found to be a debtor of 5,106 ducats, and in payment of this sum he ceded to the Duke his house adjoining the Orti Medicei.

When Francesco I. succeeded his father he commissioned Bernardo Buontalenti to build him a palace in the Orti, where he had a chemical laboratory and a furnace for smelting different metals in the hopes of discovering how to make gold, and part of Ottaviano’s house was incorporated with it. The Grand Duke left the palace to Don Antonio, his supposed son by Bianca Cappello, and Ferdinando I. confirmed the donation on the condition that he never married. Don Antonio embellished the interior, and made a beautiful garden, which he decorated with marble and bronze statues. He took a great interest in printing and had a private press, and continued the chemical experiments of the Grand Duke Francesco. Galileo was a friend of his, and Count Pier Filippo Covoni, to whose pamphlets we are indebted for the account of this palace, cites several of the Prince’s letters to him.24 After his death the Casino passed to the Cardinal Carlo de’ Medici, who employed Matteo Rosselli and other artists to fresco some of the rooms which he filled with pictures. These were distributed among the various galleries of Florence by his heir, Cosimo III.; the statues and busts were sent to the gardens of Boboli, Petraja and Castello, and the fine cabinets and tapestries were removed to the Pitti palace. For many years the house remained empty; then it was used as barracks for the bodyguard of the Grand Duke, and in 1846 it became the custom house. During the few years that Florence was the capital of United Italy, the Foreign Office was installed in the Casino, which then assumed the more serious name of Palazzo del Buontalenti. It now is the seat of the Court of Appeal, and of the Assize Court.