The historian Bartolommeo Scala, son of a miller of Colle in the Val d’Elsa, built this palace. Cosimo de’ Medici, and his son Piero after him, paid for his education, and he became Chancellor of the Republic of Florence and was Gonfalonier of Justice in 1486. His learning was undeniable, but Lorenzo the Magnificent evidently was not satisfied with his Latin style, as he privately made Poliziano correct the despatches and letters written by Scala in the name of the Republic. At length the Chancellor suspected who was the real author of the corrections and a deadly hatred ensued between the two men. The hatred was embittered by the refusal of Scala’s beautiful and clever daughter Alessandra to listen to Poliziano, and by her marriage with Michael Tarcagnota, an inferior poet, but a better-tempered and a better-looking man than the famous Agnolo Poliziano.

Guido Scala, Bartolommeo’s grandson, died childless in 1581 and left the palace to Alessandro de’ Medici, Archbishop of Florence, afterwards Pope Leo XI. It then became the property of the Counts Gheradesca who laid out a beautiful garden and now it belongs to the Meridionale Railway Company.