This quaintly shaped palace with a fine courtyard, and ending in a sharp angle at Via de’ Castellaccio, belonged to the ancient family of the Nerli, praised by Dante as still living soberly according to the good old fashion.

In the XIth century they had houses and a tower in the centre of old Florence and took their name from one Nerlo, son of Signorello di Ridolfo d’Ildebrando di Leone, who lived in 1079. Another Messer Nerlo was Consul of the city of Florence in 1196 and again in 1202. The Nerli joined the sect of the Paterines, and when Fra Piero da Verona preached a crusade against the heretics they fled and took refuge in France. Not being able to burn the living, the Friar desecrated the family tombs and burnt the corpses and the bones of their ancestors. The Nerli remained in France for a hundred and fifty years and must have abjured their heretic faith, as Cosimo the Elder recalled Francesco de Nerlo to Florence, and caused him to be made a Popolano and a Prior, the first of his house. His son Tanay became a man of great consequence in the city, and was one of the chief adversaries of Savonarola. It was at his instigation that the bell of S. Marco, with which the friars had summoned the people to their aid when Fra Girolamo was arrested, was taken to S. Miniato. Tradition says it was never tolled there but once, and that was for the funeral of Tanay Nerli. One of his sons was a good Greek scholar to whom we owe the first edition of Homer. Another son was father to the historian Filippo Nerli (1485–1536), whose Commentary is a model of pure and elegant Italian, but marred by too great a partiality to the Medici, to whom he was related through his wife Caterina Salviati, aunt of Duke Cosimo I. The descendant of another son was Archbishop of Florence and a Cardinal in 1669. About the same time his brother, Senator Nerli, bought the estate of Rassina from the Altieri with the title of Marquess, and one of his sons succeeded his uncle as Archbishop and as Cardinal. The palace now belongs to Signor Fiaschi Cuccoli.