Of the old Serristori palace but little remains as it was incorporated in the large new building in 1873. It was chiefly interesting because the arch-traitor Malatesta Baglioni, who sold Florence to Charles V. and Clement VII., had his head-quarters there during the siege of 1530.

A certain Ser Ristoro came from Figline in 1384 and became notary to the Signoria, and from him descend the family of Serristori who gave ten Gonfaloniers and twenty-seven Priors to Florence. They were staunch adherents of the Medici until the time of Alessandro, when Francesco and his sons Gugliemo and Niccolò were exiled as rebels. Niccolò joined Filippo Strozzi against Cosimo I., was taken prisoner at Montemurlo and imprisoned for life at Volterra.

The Senator Serristori was Minister for Foreign Affairs under the Grand Duke Ferdinando III. His son Luigi served for a time in the Russian army, and afterwards became Governor of Siena, and of Pisa in 1845, when the last Grand Duke of Tuscany revived in his favour the title of Count Palatine, bestowed on an ancestor of his in 1439 by the Emperor Paleologus. His son Alfredo went to Constantinople and acted as adjutant to Omer Pasha during the Crimean war. In 1858 he filled the same post to General Cialdini and assisted at the campaigns fought for the Unity of Italy. He died unmarried and was succeeded by the son of his sister, who took the name of Serristori.