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Piebald rats and selection

Chapter 75: Plate 1.
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About This Book

Investigators present a controlled breeding study that tests whether Mendelian determiners remain unchanged during crosses by selecting for increased or decreased pigmentation in piebald coat patterns of laboratory rats. They describe methods for grading dorsal pigmentation, establish parallel plus and minus selection lines, perform return and hybrid crosses with different stocks, and tabulate multigenerational outcomes. Statistical summaries and plates illustrate shifts in pigment distribution and the response to selection. The results are analyzed with respect to the theory of pure gametes and genotype–phenotype distinctions, showing that extracted recessive patterns and selection responses complicate simple notions of gametic purity.

EXPLANATION OF PLATES.

Plate 1.

Top row, a set of arbitrary grades used in the classification of the rats studied.

Middle and bottom rows, skins of rats graded as indicated by the numerals above each skin. The animals graded, +4, +4¼ and +4¾, being entirely dark above, are shown in ventral view.

PLATE 1

Plate 2.

♂ 8000, a wild gray rat caught in Cambridge, Mass., October, 1908.

♀ 6176, a black hooded rat of grade -1¾ which was mated with ♂ 8000.

♂ 8021 and ♂ 8018, F₁ offspring of the pair just described, ♂ 8000 and ♀ 6176. ♂ 8021 is of grade +4¾, with considerable white below. Notice also his white legs and compare with those of his father. ♂ 8018 is of grade +5½. Notice white areas on belly and front legs.

8075-8078, four F₂ progeny (grandchildren) of ♂ 8000 and ♀ 6176. 8075 is black hooded, grade ¾; 8076 is gray, +4¼; 8077 is gray, +4; 8078 is black, +5½.

PLATE 2

Plate 3.

♂ 103, an evenly marked rat of grade +3. A female rat of this same grade was mated with ♂ 8000 (the wild gray male). Two litters of F₂ grandchildren are shown in 8062-8067, and 8070-8074.

8062 is black hooded, +2; 8064 is gray hooded, +2; 8065 is black, +5; 8066 is gray, +5¼; 8067 is gray, +4½ (notice white feet).

8070 is black hooded, +2; 8071 is gray hooded, +1¾; 8072 is gray, +5; 8073 is black, +5½; 8074 is gray, +5¾.

PLATE 3