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Piebald rats and selection

By William E. Castle
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About This Book

Investigators present a controlled breeding study that tests whether Mendelian determiners remain unchanged during crosses by selecting for increased or decreased pigmentation in piebald coat patterns of laboratory rats. They describe methods for grading dorsal pigmentation, establish parallel plus and minus selection lines, perform return and hybrid crosses with different stocks, and tabulate multigenerational outcomes. Statistical summaries and plates illustrate shifts in pigment distribution and the response to selection. The results are analyzed with respect to the theory of pure gametes and genotype–phenotype distinctions, showing that extracted recessive patterns and selection responses complicate simple notions of gametic purity.

About the Author

Castle, William E. portrait

William E. Castle

William E. Castle was an American geneticist known for his pioneering work in the field of genetics and animal breeding. He made significant contributions to the understanding of inheritance patterns, particularly through his studies on the genetics of rats. His notable work, "Piebald Rats and Selection," explores the genetic mechanisms behind coat color variations in rats, providing insights that have implications for broader genetic research. Castle's research laid foundational principles that influenced future studies in genetics and animal husbandry.

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