There is some reason to believe also that the weather or period of the season influences some of the esculent species. Thus Foderé has mentioned instances of the common morelle having appeared injurious after long-continued rain.[2417]
Even the Agaricus campestris or common mushroom is generally believed to become somewhat unsafe towards the close of the season, or as it turns old. Its external characters at that time are sensibly altered; the margin of the cap is more acute, its white colour less lively, and the fleshy hue of its lamellæ is changed to brown or black. In this state, however, I have often eaten it freely and with impunity.
Cooking produces some difference on their effects. The very best of them are indigestible when raw; and some of the poisonous species may lose in part their deleterious qualities when cooked, because heat expels the volatile principle; but, on the whole, I believe the effect of cooking has not been satisfactorily shown to be considerable. Dr. Pouchet of Rouen seems to have clearly proved, that the poisonous properties of two of the most deadly fungi, the Amanita muscaria and A. venenata, may be entirely removed by boiling them in water. A quart of water, in which five plants had been boiled for fifteen minutes, killed a dog in eight hours, and again another in a day; but the boiled fungi themselves had no effect at all on two other dogs; and a third, which had been fed for two months on little else than boiled amanitas, not only sustained no harm, but actually got fat on this fare.[2418] Pouchet is inclined to think that the whole poisonous plants of the family are similarly circumstanced.—On the other hand some cryptogamous botanists have maintained that the qualities of the esculent mushrooms are injured by cooking, and that when used in the raw state they may be taken for a long time as a principal article of food without injury. This statement, as to the effect of mushrooms when used for a length of time as food, will be more fully considered presently. It is easy to understand how boiling may remove their active properties, although other modes of cookery may not do so. Roasting had no effect in impairing the activity of Agaricus procerus in the case observed by Dr. Peddie.
On certain persons all mushrooms, even the very best of the eatable kinds, act more or less injuriously. They cause vomiting, diarrhœa, and colic. In this respect they are on the same footing with the richer sorts of fish, which by idiosyncrasy act as poisons on particular constitutions. It is probably under this head that we must arrange an extraordinary case mentioned by Sage of a man who died soon after eating a pound of truffles. He was seized with headache, a sense of weight in the stomach, and faintness; and he lived only a few hours.[2419]
Lastly, it is not improbable from a singular set of cases to be related presently, that, contrary to what some botanists have alleged, the best mushrooms when taken in large quantity, and for a considerable length of time, are deleterious to every one.
Foderé,[2420] Orfila,[2421] Decandolle,[2422] and Greville,[2423] have laid down general directions for distinguishing the esculent from the poisonous varieties; but it is extremely questionable whether their rules are always safe; and certainly they are not always accurate, as they would exclude many species in common use on the continent. It appears that most fungi which have a warty cap, more especially fragments of membrane adhering to their upper surface, are poisonous. Heavy fungi, which have an unpleasant odour, especially if they emerge from a vulva or bag, are also generally hurtful. Of those which grow in woods and shady places a few are esculent, but most are unwholesome; and if moist on the surface they should be avoided. All those which grow in tufts or clusters from the trunks or stumps of trees ought likewise to be shunned. A sure test of a poisonous fungus is an astringent, styptic taste, and perhaps also a disagreeable, but certainly a pungent, odour. Some fungi possessing these properties have indeed found their way to the epicure’s table; but they are of very questionable quality. Those whose substance becomes blue soon after being cut are invariably poisonous. Agarics of an orange or rose-red colour, and boleti which are coriaceous or corky, or which have a membranous collar round the stem, are also unsafe; but these rules are not universally applicable in other genera. Even the esculent mushrooms, if partially devoured and abandoned by insects, are avoided by some as having in all probability acquired injurious qualities which they do not usually possess; but this test I have often disregarded.—These rules for knowing deleterious fungi seem to rest on fact and experience; but they will not enable the collector to recognise every poisonous species. The general rules laid down for distinguishing wholesome fungi are not so well founded, and therefore it appears necessary to specify them.
On the Poisonous Principle of the Fungi.—Few attempts have been hitherto made to discover by chemical analysis the principles on which the effects of the poisonous mushrooms depend. M. Braconnot analyzed a considerable number both of the esculent and poisonous species, and found in some a saccharine matter, in others an acrid resin, in others an acrid volatile principle, and in all a spongy substance, which forms the basis of them, and which he has denominated fungin.[2424] The last ingredient is innocuous, and it does not appear that M. Braconnot could trace the peculiar powers of the fungi to any of the acrid principles. The subject was afterwards resumed by M. Letellier, who says he found in some of them one, in others two poisonous principles. One of these is an acrid matter so fugacious, that it disappears when the plant is either dried, or boiled, or macerated in weak acids, alkalis, or alcohol. To this principle he says are owing the irritant properties of some fungi. The other principle is more fixed, as it resists drying, boiling, and the action of weak alkalis and acids. It is soluble in water, has neither smell nor taste, and forms crystallizable salts with acids; but he did not succeed in separating it in a state of purity. To this principle he attributes the narcotic properties of the fungi. He found it in the Amanita bulbosa, muscaria, and verna; and he therefore proposed to call it amanitine. Its effects on animals appear to resemble considerably those of opium.[2425]—Chansarel found that the poisonous principle resides in the juice, and not in the fleshy part after it is well washed.[2426]
Of the Symptoms produced in Man by the Poisonous Fungi.—The mode of action of the poisonous fungi has not been particularly examined; but the experiments of Paulet long ago established that they are poisonous to animals as well as to man.[2427]
The symptoms produced by them in man are endless in variety, and fully substantiate the propriety of arranging them in the class of narcotico-acrid poisons. Sometimes they produce narcotic symptoms alone, sometimes only symptoms of irritation, but much more commonly both together. It is likewise not improbable, that fungi, even though not belonging to the varieties commonly acknowledged as poisons, induce, when taken for a considerable length of time, a peculiar depraved state of the constitution, leading to external suppuration and gangrene. Each of these statements will now be illustrated by a few examples.
The following is a good instance of pure narcotism. A man gathered in Hyde Park a considerable number of the Agaricus campanulatus by mistake for the A. campestris, stewed them, and proceeded to eat them; but before ending his repast, and not above ten minutes after he began it, he was suddenly attacked with dimness of vision, giddiness, debility, trembling, and loss of recollection. In a short time he recovered so far as to be able to go in search of assistance. But he had hardly walked 250 yards when his memory again failed him, and he lost his way. His countenance expressed anxiety, he reeled about, and could hardly articulate. The pulse was slow and feeble. He soon became so drowsy that he could be kept awake only by constant dragging. Vomiting was then produced by means of sulphate of zinc; the drowsiness gradually went off; and next day he complained merely of languor and weakness.[2428]—An equally remarkable set of cases of pure narcotism, which occurred a few years ago in this city, has been related by Dr. Peddie. Half an hour after eating the Agaricus procerus, an elderly man and a boy of thirteen were attacked with giddiness and staggering, as if they were intoxicated; and in an hour they became insensible, the man indeed so much so that for some time he could not be roused by any means. Emetics having little effect, the stomach was cleared out by the pump, and powerful stimulants were employed both inwardly and outwardly, by means of which sensibility was in some degree restored. Occasional convulsive spasms ensued, and afterwards furious delirium, attended with frantic cries and vehement resistance to remedies, and followed by a state like delirium tremens. The pupils were at first much contracted, afterwards considerably dilated as sensibility returned, and in the boy contracted while he lay torpid, but dilated when he was roused. In neither instance was there any pain felt at any time; nor were the bowels affected. Another boy who took a small quantity only had no other symptom but giddiness, drowsiness, and debility.[2429]—A singular form of the narcotic effects of the fungi occurred in the case of a boy of fourteen, who had eaten the Agaricus panterinus near Bologna. In the course of two hours he was seized with delirium, a maniacal disposition to rove, and some convulsive movements. Ere long these symptoms were succeeded by a state resembling coma in every way, except that he looked as if he understood what was going on: and in point of fact really did so. He recovered speedily under the use of emetics.[2430]
In the next set of cases the symptoms were those of almost pure irritation. Several French soldiers in Russia ate a large quantity of the Amanita muscaria, which they had mistaken for the Amanita cæsarea. Some were not taken ill for six hours and upwards. Four of them, who were very powerful men, thought themselves safe, because while their companions were already suffering, they themselves felt perfectly well; and they refused to take emetics. In the evening, however, they began to complain of anxiety, a sense of suffocation, frequent fainting, burning thirst, and violent gripes. The pulse became small and irregular, and the body bedewed with cold sweat; the lineaments of the countenance were singularly changed, the nose and lips acquiring a violet tint; they trembled much; the belly swelled, and a profuse fetid diarrhœa supervened. The extremities soon became livid, and the pain of the abdomen intense; delirium ensued; and all four died.[2431]
Such cases, however, do not appear to be very common; and much more generally the symptoms of poisoning with the fungi present a well-marked conjunction of deep narcotism and violent irritation, as the instances now to be mentioned will show.
Besides the four soldiers whose cases have just been described, several of their comrades were severely affected, but recovered. Two of these had weak pulse, tense and painful belly, partial cold sweats, fetid breath and stools. In the afternoon they became delirious, then comatose, and the coma lasted twenty-four hours.
A man, his wife, and three children, ate to dinner carp stewed by mistake with the Amanita citrina. The wife, the servant, and one of the children had vomiting, followed by deep sopor; but they recovered. The husband had true and violent cholera, but recovered also. The two other children became profoundly lethargic and comatose, emetics had no effect, and death soon ensued without any other remarkable symptom. The individuals who recovered were not completely well till three weeks after the fatal repast.[2432] This set of cases shows the tendency of the poisonous fungi to cause in one person pure irritation, and in another pure narcotism.
The last set of cases to be mentioned were produced by the Hypophyllum sanguineum, a small conical fungus of a mouse colour, well known to children in Scotland by the name of puddock-stool. This species seems to cause convulsions as well as sopor. A family of six persons, four of whom were children, ate about two pounds of it dressed with butter. The incipient symptoms were pain in the pit of the stomach, a sense of impending suffocation, and violent efforts to vomit; which symptoms did not commence in any of them till about twelve hours after the poisonous meal, in one not till twenty hours, and in another not till nearly thirty hours. One of the children, seven years of age, had acute pain of the belly, which soon swelled enormously; afterwards he fell into a state of lethargic sleep, but continued to cry; about twenty-four hours after eating the fungi the limbs became affected with permanent spasms and convulsive fits; and in no long time he expired in a tetanic paroxysm. Another of the children, ten years old, perished nearly in the same manner, but with convulsions of greater violence. The mother had frequent bloody stools and vomiting; the skin became yellow; the muscles of the abdomen were contracted spasmodically, so that the navel was drawn towards the spine; profound lethargy and general coldness supervened; and she too died about thirty-six hours after eating the fungus. A third child, after slight symptoms of amendment had shown themselves, became worse again, and died on the third day with trembling, delirium, and convulsions. This patient, who had taken very little of the poison, was not attacked till about thirty hours after the meal. The fourth child, after precursory symptoms like those of the rest, became delirious, and had an attack of colic and inflammation of the bowels, without diarrhœa; but he eventually recovered. The father had a severe attack of dysentery for three days, and remained five days speechless. For a long time afterwards he had occasional bloody diarrhœa; and, although he eventually recovered, his health continued to suffer for an entire year.[2433] The cases now mentioned illustrate clearly the simultaneous occurrence of narcotic and irritant symptoms in the same individuals.
A striking circumstance in respect to the symptoms of poisoning with the fungi, is the great difference in the interval which elapses before they begin. In the first case the symptoms appear to have commenced in a few minutes; but, on the contrary, an interval of twelve hours is common; and Gmelin has quoted a set of cases, seventeen in number, in which, as in one of those related by Picco, the interval is said to have been a day and a half.[2434] The tardiness of the approach of the symptoms is owing to the indigestibility of most of the fungi. Their indigestibility is in fact so great, that portions of them have been discharged by vomiting so late as fifty-two hours after they were swallowed.[2435]
Another circumstance, worthy of particular notice, is the great durability of the symptoms. Even the purely narcotic effects of some fungi have been known to last above two days. In the instance just alluded to, the vomiting of the poison was the first thing that interrupted a state of deep lethargy, which had prevailed for fifty-two hours. The symptoms of irritation, after their violence has been mitigated, might continue, as in the instance quoted from Orfila, for about three weeks.
It was stated above, that some people are apt to suffer unpleasant effects from eating even the best and safest of the esculent mushrooms. These effects, which depend on idiosyncrasy, are confined chiefly to an attack of vomiting and purging, followed by more or less indigestion. Some persons have been similarly affected, even by the small portion of mushroom-juice which is contained in an ordinary ketchup seasoning. This accident, however, may very well be often unconnected with idiosyncrasy; as I have seen those who gather mushrooms near Edinburgh, for the purpose of making ketchup, picking up every fungus that came in their way.
There is some reason for suspecting that even the best mushrooms, when taken as a principal article of food for a considerable length of time, will prove injurious, and that they then induce a peculiar depraved habit, which leads to external suppuration and gangrene. The only cases which have hitherto appeared in support of this statement, were lately published in Rust’s Journal. A family, consisting of the mother and four children, were seized with a kind of tertian fever, and the formation of abscesses, which discharged a thin, ill-conditioned pus, passed rapidly into spreading gangrene, and proved fatal to the mother and one of the children. No other cause could be discovered to account for so extraordinary a conjunction of symptoms in so many individuals, except that for two months they had lived almost entirely on mushrooms; and the probability of this being really the cause, was strengthened by the fact, that the father who slept always with his family, and who alone escaped, lived on ordinary food at a place where he worked not far off.[2436] In opposition, however, to the natural inference from this narrative, some have believed, that mushrooms may be safely eaten to a large amount and for a long time, provided they be used raw. A botanist of Persoon’s acquaintance, while studying the cryptogamous plants in the vicinity of Nuremberg, says he found that the peasants ate them in large quantities as their daily food; and, in imitation of their custom, he ate for several weeks nothing but bread and raw mushrooms; yet at the end he experienced an increase rather than a diminution of strength, and enjoyed perfect health. He adds that they lose their good qualities by cooking; but he has supplied no facts in support of that statement.[2437] It is said that eatable fungi, used for a considerable time as a principal article of food, as in Russia, cause greenness of the skin.[2438] There is no reason for supposing, as some have done,[2439] that wholesome mushrooms may produce the effects of the poisonous kinds, if eaten in large quantity.
Of the Morbid Appearances.—The morbid appearances left in the bodies of persons poisoned by this deleterious fungi have been but imperfectly collected.
The body is in general very livid, and the blood fluid; so much so sometimes, that it flows from the natural openings in the dead body.[2440] In general, the abdomen is distended with fetid air, which, indeed, is usually present during life. The stomach and small intestines of the four French soldiers (p. 705), presented the appearance of inflammation passing in some places to gangrene. In two of them especially, the stomach was gangrenous in many places, and far advanced in putrefaction. The same appearances were found in Picco’s cases. In these there was also an excessive enlargement of the liver. The lungs have sometimes been found gorged or even inflamed. The vessels of the brain are also sometimes very turgid. They were particularly so in a case related by Dr. Beck, where death was occasioned in seven hours by an infusion of the Amanita muscaria in milk. The whole sinuses of the dura mater, as well as the arteries were enormously distended with blood; the arachnoid and pia mater were of a scarlet colour; the vessels of the membrane between the convolutions, together with the plexus choroides, were also excessively gorged; and the substance of the brain was red. Lastly, a clot of blood, as big as a bean, was found in the cerebellum.[2441]—The stomach, unless there had been vomiting or diarrhœa, will usually contain fragments of the poison, if it has not been taken in a state of minute division; and this evidence of the cause of death may be obtained, even although the individual survived two days or upwards. Sometimes fragments are found in the intestines. In one of Picco’s patients who lived twenty-four hours, there was found in the neighbourhood of the ileo-cæcal valve, which was much inflamed.[2442]
Of the Treatment.—The treatment of poisoning with the fungi does not call for any special observations. Emetics are of primary importance; and after the poison has been by their means dislodged, the sopor and inflammation of the bowels are to be treated in the usual way. No antidote is known. Several have at different times been a good deal confided in; but none are of any material service. Chansarel found acids useless, but thought infusion of galls advantageous.[2443]
In concluding the present chapter it is necessary to take notice of a variety of poisoning, not altogether unimportant in a medico-legal point of view. A person may seem to die of poisoning with the deleterious fungi, from eating esculent mushrooms intentionally drugged with some other vegetable or mineral poison. It must be confessed, that if the murderer is dexterous in the choice and mode of administering the poison, such cases might readily escape suspicion, and even when suspected might not be cleared up without difficulty. The ascertaining the species of mushroom, by finding others where it has been gathered, will not supply more than presumptive proof of the wholesomeness of that which has been eaten; because the esculent and poisonous species sometimes grow near one another, and have a mutual resemblance, so that a mistake may easily occur. The presumption may be somewhat strengthened by evidence derived from the interval which elapses before the symptoms begin, from the nature and progress of the symptoms themselves, and from the morbid appearances. Some one or other of these circumstances may establish the fact of poisoning with a deleterious fungi. It is impossible, however, that they shall ever establish satisfactorily that the fungus was naturally wholesome; and, on the whole, the only decided evidence of poisoning by some other means will be the actual discovery of another poison.
The case now under consideration is not a mere hypothetical one. Ernest Platner has related a very interesting example, which proves how easily poisoning of the kind supposed may be accomplished without suspicion. A servant-girl poisoned her mistress by mixing oxide of arsenic with a dish of mushrooms. She died in twenty hours, after suffering severely from vomiting and colic pains. On dissection there were found inflammation of the stomach, gangrenous spots in it, clots of blood in its contents, and redness of the intestines. Her death, however, was ascribed to the mushrooms having been unwholesome; and the real cause was not discovered till thirteen years after, when the girl was convicted of murdering a fellow-servant in a somewhat similar way by mixing arsenic with her chocolate, and then confessed both crimes.[2444]
Poisonous Mosses.—It is not improbable that some of the mosses possess poisonous properties similar to those of the deleterious fungi. Dr. Winkler of Innsbruch mentions that the Lycopodium selago is used in the Tyrol in the way of infusion for killing vermin on animals; and that unpleasant accidents have been produced in man by its accidental use. Its effects appear to be sometimes irritant, but more generally narcotic in their nature.[2445]
The different sorts of grain are subject to certain diseases, in consequence of which meal or flour made from them is apt to be impregnated with substances more or less injurious to animal life. It is likewise believed, that unripe grain possesses properties which render it to a certain extent unfit for the food of man.
It is for the most part difficult to trace satisfactorily the operation of the poisons now alluded to, because they are seen acting only in times of famine and general distress, when it is not always easy to make due allowance for the effect of collateral circumstances. There is one poison of the kind, however, whose baneful influence has been so frequently and unequivocally witnessed, that no doubt now exists regarding its properties, I mean spurred rye, or ergot. It is a poison of no great consequence, perhaps, to the English toxicologist; for indeed I am not aware that a single instance of its operation has hitherto been observed in Britain.[2446] But its effects are so singular, and the ravages it has often committed on the continent have been so dreadful, that a short account of it cannot fail to interest even the English reader. Besides, it has lately been introduced into the materia medica, as possessing very extraordinary medicinal qualities; and since its use is gaining ground, every medical jurist ought to be conversant with its properties as a poison. I have also met with an instance where it was administered for the purpose of procuring miscarriage.
Spurred Rye, or Secale cornutum, the Seigle ergoté, or Ergot of the French, and Mutterkorn, or Roggenmutter, of the Germans, is a disease common to various grains, in consequence of which the place of the pickle is supplied by a long, black substance, like a little horn or spur. It has been known to attack many plants of the order Graminaceæ;[2447] and among those used as food by man, it has been observed on barley, oats, spring-wheat, winter-wheat, and rye. But the rye seems peculiarly subject to it, almost all the poison which has caused epidemics, as well as what is now used in medicine, being produced by that grain.
Of the Cause and Nature of the Spur in Rye.—The spur attacks rye chiefly in damp seasons, and in moist clay soils, particularly those recently redeemed from waste lands in the neighbourhood of forests. Of all the places where the spur has been hitherto observed none combines these conditions so perfectly, and none has been so much infested with the disease, as the district of Sologne, situated between the rivers Loire and Cher, in France. According to the statistical researches of the Abbé Tessier, who in 1777 was deputed by the Parisian Society of Medicine to investigate the causes of the extraordinary prevalence of the ergot in that district, the country was then so much intersected by belts of wood around the fields, that the traveller in passing along might imagine he was constantly approaching an immense forest; the arable land was so poor, that, although it lay fallow every third season, it was exhausted in nine or twelve years at farthest, and then remained a long time in pasture before it could again bear white crops; the surface was so level, and consequently so wet, that crops were obtained only when the seed was sown on the tops of furrows a foot high; and the climate is so moist, that from the month of September till late in spring the whole country is overhung by dense fogs.[2448] Here the rye, the common food of the peasantry, appears to have been in Tessier’s time more liable to be attacked by the spur than in any other part of the continent. Tessier found, that after being thrashed it contained on an average about a forty-eighth part of ergot, even in good seasons; but in bad seasons, and taking into account a considerable proportion which is shaken out of the ears and sheaves before they reach the barn, the proportion of ergot in the whole crop has been estimated so high as a fourth or even a third. In Sologne the disease was farther observed by Tessier to be always most prevalent in the dampest parts of a field, and to affect above all the first crop of fields redeemed from waste land, or from land which had previously been for some time in pasture.[2449] The same connexion between moisture and the development of the ergot has been repeatedly traced in other parts of France, as well as in Germany.[2450] And according to the experiments of Wildenow, it may be brought on at any time, by sowing the rye in a rich damp soil, and watering the plants exuberantly in warm weather.[2451]
Opinions are much divided as to the cause and nature of the spur. It had been conceived by some that nothing else is required for its production but undue moisture combined with warmth; and that under these circumstances the spur is formed simply by a diseased process from the juices of the plant.[2452] By others, such as Tillet, Fontana, and Réad, who also consider it to be simply a diseased formation, it has been held to arise from the germen being punctured when young by an insect;[2453] and in support of this statement, General Field says he saw flies puncture the glumes in their milky state where spurs afterwards formed, and imitating the operation with a needle obtained the same result.[2454] On the other hand, Decandolle, reviving a previous doctrine that the spur is a kind of fungus, conceived he had given strong grounds for believing this excrescence to be a species of sclerotium, which he terms S. clavus. Wiggers supports this doctrine by chemical analysis; for he endeavours to show that the basis of the structure of the spur is almost identical in chemical properties with the principle fungin.[2455] Lastly, the most recent researches, those of Smith,[2456] Queckett,[2457] and Bauer,[2458] founded chiefly on microscopical observations, tend to a union and modification of these two views,—namely, that the great mass of the spur is a peculiar morbid formation, and that the whitish bloom which covers fresh specimens consists of a multitude of microscopic fungi in the form of sporidia, which thickly envelope and impregnate the parts of fructification in the nascent state of the embryo, and are in all probability the exciting cause of the morbid degeneration of the pickle.[2459]
Various opinions have been formed as to the mode of propagation of the spur. Fontana has alleged that one variety of it may spread from plant to plant over a field; and that he has expressly transmitted it by contact from one ear to another.[2460] His opinion and statement of facts are at variance with experiments lately made by Hertwig, a German physician, who found that even when the ear while in flower was surrounded for twelve days with powder of spurred rye, the healthiness of the future grain was not in the slightest degree affected.[2461] The same results have also been obtained by Wiggers, and more recently by Dr. Samuel Wright.[2462] Wiggers, however, although he could not produce spurs in the way indicated by Fontana, observed that the white dust on the surface of the spurs will produce the disease in any plant, if sprinkled in the soil at its roots, appearing therefore to be analogous to the sporules or spawn of the admitted fungi. Mr. Queckett has made the most precise experiments on the mode of reproduction of the disease. He succeeded in infecting rye repeatedly with ergot by means of the sporidia developed on the spurs; but it is remarkable that he could not in the same way infect wheat or barley.[2463]
Description and analysis of Spurred Rye.—The spur varies in length from a few lines to two inches, and is from two to four lines in thickness. If it is long, there is seldom more than one or two on a single ear, and the remaining pickles of the ear are healthy. But the ears which have small spurs have generally several, sometimes even twenty; and when there are many, few of the remaining pickles are altogether without blackness at the tips.[2464] The substance of the spur is of a pale grayish-red tint; and externally it is bluish-black or violet, with two, sometimes three, streaks of dotted gray. It is specifically lighter than water, while sound rye is specifically heavier, so that they are easily separated from one another.[2465] It is tough and flexible when fresh, brittle and easily pulverized when dry. The powder is disposed to attract moisture. It has a disagreeable heavy smell, a nauseous, slightly acrid taste, and imparts its taste and smell both to water and alcohol. Bread which contains it is defective in firmness, liable to become moist, and cracks and crumbles soon after being taken from the oven.[2466]—It is easily known, when entire, by its external characters. Its powder, which is of an obscure grayish-red hue, is best known by the action of solution of potash, which immediately disengages a powerful odour of ergot, and forms a lake-red pulp; and this pulp yields by filtration a splendid lake-red solution, which gives a beautiful lake-red flaky precipitate, when either neutralized by nitric acid, or treated with an excess of solution of alum.
Spurred rye has been repeatedly subjected to analysis. The earlier researches of Vauquelin[2467] and of Pettenkofer[2468] do not lead to any pointed results. The presence of hydrocyanic acid indicated by Robert,[2469] would not account for the very peculiar effects of ergot, and has besides been denied by Wiggers. Winkler obtained various principles from it, and among the rest a thick, rancid, slightly acrid oil, and a nauseous, sweetish, acrid fluid; but he did not determine, any more than his predecessors, in which of these principles the active properties of the spur reside.[2470] Wiggers supplied more definite information on the subject. He denies the presence of hydrocyanic acid, and says he found ergot to consist chiefly of a heavy-smelling fixed oil, fungin, albumen, osmazome, waxy matter, and an extractive substance of a strong, peculiar taste and smell, in which, from experiments on animals, he was led to infer that its active properties reside. I have obtained all his chief results, except the most important of them; for the substance which ought to have been his ergotin was destitute of marked taste or smell of any kind.[2471] Dr. Wright too could not obtain the ergotin of Wiggers, and concludes from his own experiments, that the spur consists of fungin, modified starch, mucilage, gluten, osmazome, colouring matter, various salts, and thirty-one per cent. of fixed oil, in which the active properties of the poison seemed to him to reside.[2472] Buchner, however, thinks that the oil is not itself active, but owes its apparent energy to an acrid principle which alcohol removes from it, and which is not removed from the crude substance in separating the oil in the usual way by sulphuric ether, unless the ether be somewhat alcoholized.[2473] However this may be, it seems ascertained by the experiments of Dr. Wright, that the fixed oil, obtained by means of common ether, concentrates in itself the peculiar properties possessed by ergot, either in small doses as a medicine, or in a single large dose as a poison.
Effects of Spurred Rye on Man and Animals.—Before proceeding to relate the effects of this poison on man, it should be mentioned, that at different times doubts have been entertained, whether the baneful effects ascribed to it might not really arise from some other cause. But independently of the connexion which has been frequently traced between the poison and the diseases imputed to it in the human subject, the question has been set at rest by the experiments which have been tried on animals, and which indeed were instituted with a view to settle the point in dispute.
The experiments hitherto made on animals are variable in their results, yet sufficient to show that spurred rye is an active poison of a very peculiar kind. According to the observations collected by Dr. Robert from a variety of authors, it follows that it is injurious and even fatal to all animals which are fed for a sufficient length of time with a moderate proportion of it, unless they escape its action by early vomiting; that dogs and cats, in consequence of discharging it by vomiting, suffer only slight symptoms of irritant poisoning;—but that swine, moles, geese, ducks, fowls, quails, sparrows, as well as leeches and flies, are sooner or later killed by it;—and that the symptoms it causes in beasts and birds are in the first instance giddiness, dilated pupil, and palsy, and afterwards diarrhœa, suppurating tumours, scattered gangrene throughout the body, and sometimes dropping off of the toes. Wiggers ascertained that nine grains of the substance he has considered its active principle occasioned in a fowl dulness, apparent suffering, gradually increasing feebleness, coldness and insensibility of the extremities, and in three days a fit of convulsions, ending in death.[2474] Taddei lately found, that sparrows were killed by six grains of it in six or seven hours, with symptoms merely of great weakness, torpor, and indisposition to stir.[2475]
Dr. Wright, whose experiments are the most extensive and precise yet made on this subject, found that a single dose, consisting of a strong infusion of between two drachms and a half and six drachms of ergot, if introduced into the jugular vein of a dog, occasions death, sometimes in a few minutes, sometimes not for more than two hours, with symptoms of alternating spasm and paralysis, occasionally a tendency to coma, and often depressed or irregular action of the heart, or even complete arrestment of its function;—that, when introduced into the cellular tissue, it produces inflammation and suppuration, sometimes circumscribed, sometimes diffuse, and always attended with an unhealthy discharge and great exhaustion;—and that, when admitted into the stomach, it excites irritation of the alimentary canal, excessive muscular prostration, at first excitability, but afterwards singular dulness or even complete obliteration of the senses, and occasional slight spasms; but that it is not a very active poison through this channel, as above three ounces are required to prove fatal to a dog. When it was administered in frequent small doses, he could not observe the effects remarked by Robert, but found that it induced a peculiar cachectic state, indicated by extreme muscular emaciation and weakness, loss of appetite, frequency of the pulse, repulsive fetor of the secretions and excretions, congestion of the alimentary mucous membrane, excessive contraction of the spleen, enlargement of the liver and absorbent glands, and non-formation of callus at the ends of fractured bones.[2476]
With regard to its effects on man, it has been found by express experiment, that a single dose of two drachms excites giddiness, headache, flushed face, pain and spasms in the stomach, nausea, and vomiting, colic, purging, and a sense of weariness and weight in the limbs.[2477] But it is not in this way that it has been usually introduced into the system; nor are these precisely the symptoms already hinted at as particular in its action. The effects now to be mentioned form a peculiar disease, which has often prevailed epidemically in different territories on the continent, and which arises from the spur being allowed to mix with the grain in the meal, and being taken as food for a continuance of time in rye-bread. The affection produced differs much in different epidemics and even in different cases of the same epidemic. Two distinct disorders have been noticed; the one a nervous disease, characterized by violent spasmodic convulsions; the other a depraved state of the constitution, which ends in that remarkable disorder, dry gangrene; and it does not appear that the two affections are apt to be blended together in the same case.
The first form of disease, the convulsive ergotism of the French writers, has been very well described by Taube, a German physician, as it occurred in the north of Germany in 1770–1. In its most acute form, it commenced suddenly with dimness of sight, giddiness and loss of sensibility, followed soon by dreadful cramps and convulsions of the whole body, risus sardonicus, yellowness of the countenance, excessive thirst, excruciating pains in the limbs and chest, and a small, often imperceptible pulse. Such cases usually proved fatal in twenty-four or forty-eight hours. In the milder cases the convulsions came on in paroxysms, were preceded for some days by weakness and weight of the limbs, and a strange feeling as of insects crawling over the legs, arms, and face; in the intervals between the fits the appetite was voracious, the pulse natural, the excretions regular; and the disease either terminated in recovery, with scattered suppurations, cutaneous eruptions, anasarca or diarrhœa, or it proved in the end fatal amidst prolonged sopor and convulsions.[2478] Another more recent and very clear account of this form of the disease has been given by Dr. Wagner of Schlieben from his experience of an epidemic which prevailed in the neighbourhood of that place so lately as the years 1831 and 1832. In consequence of unusual moisture and late frosts in the summer of 1831, the rye was so much spurred in many fields that a fifth at least of the pickles was diseased. As soon as the country people proceeded to use the new rye, convulsive ergotism began to show itself, and it recurred more or less till next midsummer, when the diseased grain was all consumed. The usual symptoms were at first periodic weariness, afterwards an uneasy sense of contraction in the hands and feet, and at length violent and permanent contraction of the flexor muscles of the arms, legs, feet, hands, fingers and toes, with frequent attacks of a sense of burning or creeping on the skin. These were the essential symptoms; but a great variety of accessory nervous affections occasionally presented themselves. There was seldom any disturbance of the mind, except in some of the fatal cases, where epileptic convulsions and coma preceded death. Every case was cured by emetics, laxatives, and frequent small doses of opium, provided it was taken in reasonable time, and the unwholesome food was completely withdrawn.[2479]
The other form of disease, which has been named gangrenous ergotism, by the French writers, and is known in Germany by the vulgar name of creeping-sickness (kriebelkrankheit), has been minutely described by various authors. In the most severe form, as it appeared in Switzerland in 1709 and 1716, it commenced, according to Lang, a physician of Lucerne, with general weakness, weariness, and a feeling as of insects creeping over the skin; when these symptoms had lasted some days or weeks, the extremities became cold, white, stiff, benumbed, and at length so insensible that deep incisions were not felt; then excruciating pains in the limbs supervened, along with fever, headache, and sometimes bleeding from the nose; finally the affected parts, and in the first instance the fingers and arms, afterwards the toes and legs, shrivelled, dried up, and dropped off by the joints. A healthy granulation succeeded; but the powers of life were frequently exhausted before that stage was reached. The appetite, as in the convulsive form of the disease, continued voracious throughout.[2480] In milder cases, as it prevailed at different times in France, nausea and vomiting attended the precursory symptoms, and the gangrenous affection was accompanied with dark vesications.[2481] In another variety, which has been witnessed in various parts of Germany, the chief symptoms were spasmodic contraction of the limbs at first, and afterwards weakness of mind, voracity and dyspepsia, which, if not followed by recovery, as generally happened, either terminated in fatuity or in fatal gangrene.[2482]
These extraordinary and formidable distempers were first referred to the operation of spurred rye in 1597 by the Marburg Medical Faculty, who witnessed the ravages of the poison in Hessia during the preceding year. Since then repeated epidemics have broken out in Germany, Bohemia, Holstein, Denmark, Sweden, Lombardy, Switzerland, and France.[2483] About the close of last century, partly in consequence of the attention of the respective governments being turned to the subject, partly by reason of the improved condition of the peasantry in these countries, and the greater rarity of seasons of famine, the epidemics became much less common or extensive. Nevertheless the creeping-sickness has been several times noticed in Germany since the present century began.[2484]
Spurred rye is now generally believed to possess another singular quality, in consequence of which it has been lately introduced into the materia medica of this and other countries,—a power of promoting the contractions of the gravid uterus. This property seems to have been long familiar to the quacks and midwives of Germany; and towards the close of last century it rendered ergot so favourite a remedy with them, that several of the German states prohibited the use of it by severe statutes.[2485] It was first fairly brought under the notice of regular accoucheurs by the physicians of the United States between the years 1807 and 1814.[2486] There appears little reason for doubting that it possesses the power of increasing the contractions of the uterus when unnaturally languid; and consequently it has been employed, apparently with frequent good effect, to hasten languid natural labour, to promote the separation of the placenta, and to quicken the contraction of the womb after delivery. These facts, however, are mentioned chiefly as preparatory to the statement, that it has been also supposed to possess the power of producing abortion, and has been actually employed for that purpose in some foreign countries, and even in this city. Accurate information is still much wanted on this subject. No other poison seems so likely to possess a peculiar property of the kind. Nevertheless it is the opinion of the best authorities, that spurred rye has no such power, except in connexion with violent constitutional injury produced by dangerous doses; and that it is endowed with the property only of accelerating natural labour, not of inducing it, particularly in the early months of pregnancy.
It seems from the experiments of Dr. Wright to have no power whatever of inducing miscarriage in the lower animals.[2487] Notwithstanding the improbability, however, of its possessing the property of bringing on abortion, it is one of the substances at present occasionally employed with the view of feloniously causing this accident. In a case of attempt to procure abortion, which occurred not long ago in this city, one of the articles repeatedly employed, but without success, was powder of spurred rye,—as I had occasion to ascertain by chemical analysis.
Of Spurred Maize.—It has been already observed, that many other plants of the Natural Family of Grasses are subject to the ergot besides rye. But the only other species in which the disease has been particularly examined is Indian corn or maize [Zea Mays]. It appears from the inquiries of M. Roullin that maize is very subject to the spur in the provinces of Neyba and Maraquita in Colombia; that the spur forms a black, pear-shaped body on the ear in place of the pickle; and that in this state the grain, which is known by the name of maïs peladero, possesses properties injurious to animal life. Its effects, however, are somewhat different from those of spurred rye. Men who eat the ergotted maize lose their hair and sometimes their teeth, but are never attacked with dry gangrene or convulsions. When swine eat it, which after a time they do with avidity, the bristles drop off, and the hind-legs become feeble and wasted. Mules likewise lose their hair, and the hoofs swell. Fowls lay their eggs without the shell. Apes and parrots, which frequent the fields of spurred maize, fall down as if drunk; and the native dogs and deer experience similar effects.[2488]