RADIX CALUMBÆ.

Botanical Origin—Jateorhiza palmata Miers[104] a diœcious perennial plant, with large fleshy roots and herbaceous annual stems, climbing over bushes and to the tops of lofty trees. The leaves are of large size and on long stalks, palmate-lobed and membranous. The male flowers are in racemose panicles a foot or more in length, setose-hispid at least in their lower part, or nearly glabrous. The whole part is more or less hispid with spreading setæ and glandular hairs.

It is indigenous to the forests of Eastern Africa between Ibo or Oibo, the most northerly of the Portuguese settlements (lat. 12° 28′ S.), and the banks of the Zambesi, a strip of coast which includes the towns of Mozambique and Quilimane. Kirk found it (1860) in abundance at Shupanga, among the hills near Morambala, at Kebrabasa and near Senna, localities all in the region of the Zambesi. Peters[105] states that on the islands of Ibo and Mozambique the plant is cultivated. In the Kew Herbarium is a specimen from the interior of Madagascar.

The plant was introduced into Mauritius a century ago in the time of the French governor Le Poivre, but seems to have been lost, for after many attempts it was again introduced in 1825 by living specimens procured from Ibo by Captain Owen.[106] It still thrives there in the Botanical Garden of Pamplemousses.

It was taken from Mozambique to India in 1805 and afterwards cultivated by Roxburgh in the Calcutta Garden, where however it has long ceased to exist.

History—The root is held in high esteem among the natives of Eastern Africa who call it Kalumb, and use it for the cure of dysentery and as a general remedy for almost any disorder.

It was brought to Europe by the Portuguese in the 17th century, and is first noticed briefly in 1671 by Francesco Redi, who speaks of it[107] as an antidote to poison deserving trial.

No further attention was paid to the drug for nearly a century, when Percival[108] in 1773 re-introduced it as “a medicine of considerable efficacy ... not so generally known in practice as it deserves to be.” From this period it began to come into general use. J. Gurney Bevan, a London druggist, writing to a correspondent in 1777 alludes to it as—“an article not yet much dealt in and subject to great fluctuation.” It was in fact at this period extremely dear, and in Mr. Bevan’s stock-books is valued in 1776 and 1777 at 30s. per lb., in 1780 at 28s., 1781 at 64s., 1782 at 15s., 1783 at 6s. Calumba was admitted to the London Pharmacopœia in 1788.

Collection—As to the collection and preparation of the drug for the market, the only account we possess is that obtained by Dr. Berry,[109] which states that the roots are dug up in the month of March, which is the dry season, cut into slices and dried in the shade.

Description—The calumba plant produces great fusiform fleshy roots growing several together from a short head. Some fresh specimens sent to one of us (H.) from the Botanic Garden, Mauritius, in 1866, and others from that of Trinidad in 1868, were portions of cylindrical roots, 3 to 4 inches in diameter, externally rough and brown and internally firm, fleshy, and of a brilliant yellow. When sliced transversely, and dried by a gentle heat, these roots exactly resemble imported calumba except for being much fresher and brighter.

The calumba of commerce consists of irregular flattish pieces of a circular or oval outline, 1 to 2 inches or more in diameter, and ⅛ to ½ an inch thick. In drying, the central portion contracts more than the exterior: hence the pieces are thinnest in the middle. The outer edge is invested with a brown wrinkled layer which covers a corky bark about ⅜ of an inch thick, surrounding a pithless internal substance, from which it is separated by a fine dark shaded line. The pieces are light and of a corky texture, easily breaking with a mealy fracture. Their colour is a dull greenish yellow, brighter when the outer surface is shaved off with a knife.[110] The drug has a weak musty odour and a rather nauseous bitter taste. It often arrives much perforated by insects, but seems not liable to such depredations here.

Microscopic Structure—On a transverse section the root exhibits a circle of radiate vascular bundles only in the layer immediately connected with the cambial zone; they project much less distinctly into the cortical part. The tissue of the whole root, except the cork and vascular bundles, is made up of large parenchymatous cells. In the outer part of the bark, some of them have their yellow walls thickened and are loaded with fine crystals of oxalate of calcium, whilst all the other cells contain very large starch granules, attaining as much as 90 mkm. The short fracture of the root is due to the absence of a proper ligneous or liber tissue.

Chemical Composition—The bitter taste of calumba, and probably likewise its medicinal properties, are due to three distinct substances, Columbin, Berberine, and Columbic Acid.

Columbin, or Columba-Bitter was discovered by Wittstock in 1830. It is a neutral bitter principle, crystallizing in colourless rhombic prisms, slightly soluble in cold alcohol or ether, but dissolving more freely in those liquids when boiling. It is soluble in aqueous alkalis and in acetic acid.

The presence of Berberine in calumba was ascertained in 1848 by Bödeker, who showed that the yellow cell-walls of the root owe their colour to it and (as we may add) to Columbic Acid, another substance discovered by the same chemist in the following year. Columbic Acid is yellow, amorphous, nearly insoluble in cold water, but dissolving in alcohol and in alkaline solutions. It tastes somewhat less bitter than columbin. Bödeker surmises that it may exist in combination with the berberine.

Bödeker has pointed out a connection between the three bitter principles of calumba. If we suppose a molecule of ammonia, NH₃, to be added to columbin C₄₂H₄₄O₁₄, the complex molecule thence resulting will contain the elements of berberine C₂₀H₁₇NO₄, columbic acid C₂₂H₂₄O₇, and water 3H₂O.

Among the more usual constituents of plants, calumba contains (in addition to starch) pectin, gum, and nitrate of potassium, but no tannic acid. It yields when incinerated 6 per cent. of ash.

Commerce—Calumba root is shipped to Europe and India from Mozambique and Zanzibar, and exported from Bombay and other Indian ports.

Uses—It is much employed as a mild tonic, chiefly in the form of tincture or of aqueous infusion.

PAREIRA BRAVA.

Botanical Origin—Chondodendron tomentosum Ruiz et Pav. (non Eichler) (Cocculus Chondodendron DC., Botryopsis platyphylla Miers[112]).—It is a lofty climbing shrub with long woody stems, and leaves as much as a foot in length. The latter are of variable form, but mostly broadly ovate, rounded or pointed at the extremity, slightly cordate at the base, and having long petioles. They are smooth on the upper side; on the under covered between the veins with a fine close tomentum of an ashy hue. The flowers are unisexual, racemose, minute, produced either from the young shoots or from the woody stems. The fruits are ¾ of an inch long, oval, black and much resembling grapes in form and arrangement.[113]

The plant grows in Peru and Brazil,—in the latter country in the neighbourhood of Rio de Janeiro, where it occurs in some abundance on the range of hills separating the Copacabana from the basin of the Rio de Janeiro. It is also found about San Sebastian further south.

History—The Portuguese missionaries who visited Brazil in the 17th century became acquainted with a root known to the natives as Abutua or Butua, which was regarded as possessing great virtues. As the plant affording it was a tall climbing shrub with large, simple, long-stalked leaves, and bore bunches of oval berries resembling grapes, the Portuguese gave it the name of Parreira brava or Wild Vine.

The root was brought to Lisbon where its reputed medicinal powers attracted the notice of many persons, and among others of Michel Amelot, ambassador of Louis XIV., who took back some of it when he returned to Paris in 1688. Specimens of the drug also reached the botanist Tournefort, and one presented by him to Pomet was figured and described by the latter in 1694.[114] The drug was again brought to Paris by Louis-Raulin Rouillé, the successor to Amelot at Lisbon, together with a memoir detailing its numerous virtues.

Specimens obtained in Brazil by a naval officer named De la Mare in the early part of the last century, were laid before the French Academy, which body requested a report upon them from Geoffroy, professor of medicine and pharmacy in the College of France, who was already somewhat acquainted with the new medicine. He reported many favourable trials in cases of inflammations of the bladder and suppression of urine.[115] The drug was a favourite remedy of Helvetius,[116] physician to Louis XIV. and Louis XV., who administered it for years with great success.

Both Geoffroy and Helvetius were in frequent correspondence with Sloane[117] who received from the former as well as from other sources specimens of Pareira Brava, which are still in the British Museum and have enabled us fully to identify the drug as the root of Chondodendron tomentosum.

Several other plants of the order Menispermaceæ have stems or roots employed in South America in the same manner as Chondodendron. Pomet had heard of two varieties of Pareira Brava, and two were known to Geoffroy.[118] Lochner of Nürnberg who published a treatise on Pareira Brava in 1719[119] brought forward a plant of Eastern Africa figured in 1675 by Zanoni,[120] and supposed to be the mother plant of the drug. A species of Cissampelos called by the Portuguese in Brazil Caapeba, Cipó de Cobras or Herva de Nossa Senhora described by Piso in 1648,[121] afterwards became associated with Pareira Brava on account of similarity of properties.

Thus was introduced a confusion which we may say was consolidated when Linnæus in 1753,[122] founded a species as Cissampelos Pareira, citing it as the source of Pareira Brava,—a confusion which has lasted for more than a hundred years. This plant is very distinct from that yielding true Pareira Brava, and though its roots and stems are used medicinally in the West Indies,[123] there is nothing to prove that they were ever an object of export to Europe.

As Pareira Brava failed to realise the extravagant pretensions claimed for it, it gradually fell out of use,[124] and the characters of the true drug became forgotten. This at least seems to be the explanation of the fact that for many years past the Pareira Brava found in the shops and supposed to be genuine is a substance very diverse from the original drug,—albeit not devoid of medicinal properties. More recently even this has become scarce, and an inert Pareira Brava has been almost the sole kind obtainable. The true drug has however still at times appeared in the European market, and attention having been directed to it,[125] we may hope that it will arrive in a regular manner.

The re-introduction of Pareira Brava into medical practice is due (so far as Great Britain is concerned) to Brodie[126] who recommended it in 1828 for inflammation of the bladder.

Description—True Pareira Brava as derived from Chondodendron tomentosum is a long, branching, woody root, attaining 2 inches or more in diameter, but usually met with much smaller and dividing into rootlets no thicker than a quill or even than a horse-hair. It is remarkably tortuous or serpentine and marked with transverse ridges as well as with constrictions and cracks more or less conspicuous; besides which the surface is strongly wrinkled longitudinally. The bark is of a dark blackish brown or even quite black when free from earth, and disposed to exfoliate. The root breaks with a coarse fibrous fracture; the inner substance is of a light yellowish-brown,—sometimes of a dull greenish brown.

Roots of about an inch in diameter cut transversely exhibit a central column 0·2 to 0·4 of an inch in diameter composed of 10 to 20 converging wedges of large-pored woody tissue with 3 or 4 zones divided from each other by a wavy light-coloured line. Crossing these zones are wedge-shaped woody rays, often rather sparsely and irregularly distributed. The interradial substance has a close, resinous, waxy appearance.

The root though hard is easily shaved with a knife, some pieces giving the impression when cut of a waxy, rather than of a woody and fibrous substance. The taste is bitter, well marked but not persistent. The drug has no particular odour. Its aqueous decoction is turned inky bluish-black by tincture of iodine.

The aerial stems especially differ by enclosing a small but well-defined pith.

Microscopic Structure—The most interesting character consists in the arrangement rather than in the peculiarity of the tissues composing this drug. The wavy light-coloured lines already mentioned are built up partly of sclerenchymatous cells. The other portions of the parenchyme are loaded with large starch granules, which are much less abundant in the stem.

Chemical Composition—From the examination of this drug made by one of us in 1869,[127] it was shown that the bitter principle is the same as that discovered in 1839 by Wiggers in the drug hereafter described as Common False Pareira Brava, and named by him Pelosine. It was further pointed out that this body possesses the chemical properties of the Bibirine of Greenheart bark and of the Buxine obtained by Walz from the bark of Buxus sempervirens L. It was also obtained on the same occasion (1869) from the stems and roots of Cissampelos Pareira L. collected in Jamaica; but from both drugs in the very small proportion of about ½ per cent.

Whether to Buxine (for by this name rather than Pelosine it should be designated) is due the medicinal power of the drug may well be doubted. No further chemical examination of true Pareira Brava has been made.

Uses—The medicine is prescribed in chronic catarrhal affections of the bladder and in calculus. From its extensive use in Brazil[128] it seems deserving of trial in other complaints. Helvetius used to give it in substance, which in 5-grain doses was taken in infusion made with boiling water from the powdered root and not strained.

Substitutes—We have already pointed out how the name Pareira Brava has been applied to several other drugs than that described in the foregoing pages. We shall now briefly notice the more important.

1. Stems and roots of Cissampelos Pareira L.—Owing to the difficulty of obtaining good Pareira Brava in the London market, although this plant is very widely diffused over all the tropical regions of both hemispheres, the firm of which one of us was formerly a member (Messrs. Allen and Hanburys, Plough Court, Lombard Street) caused to be collected in Jamaica, under the superintendence of Mr. N. Wilson, of the Bath Botanical Gardens, the stems and root of Cissampelos Pareira L., of which it imported in 1866-67-68 about 300 lb. It was found impracticable to obtain the root per se; and the greater bulk of the drug consisted of long cylindrical stems,[129] many of which had been decumbent and had thrown out rootlets at the joints. They had very much the aspect of the climbing stems of Clematis vitalba L., and varied from the thickness of a quill to that of the forefinger, seldom attaining the diameter of an inch. The stems have a light brown bark marked longitudinally with shallow furrows and wrinkles, which sometimes take a spiral direction. Knots one to three feet apart, sometimes throwing out a branch, also occur. The root is rather darker in colour, but not very different in structure from the stem.

The fracture of the stem is coarse and fibrous. The transverse section, whether of stem or root, shows a thickish, corky bark surrounding a light brown wood composed of a number of converging wedges (10 to 20) of very porous structure, separated by narrow medullary rays. There are no concentric layers of wood,[130] nor is the arrangement of the wedges oblique as in many other stems of the order. The drug is inodorous, but has a very bitter taste without sweetness or astringency.

2. Common False Pareira Brava—Under this name we designate the drug which for many years past has been the ordinary Pareira Brava of the shops, and regarded until lately as derived from Cissampelos Pareira L. We have long endeavoured to ascertain, through correspondents in Brazil, from what plant it is derived, but without success. We only know that it belongs to the order Menispermaceæ.

The drug consists of a ponderous, woody, tortuous stem and root, occurring in pieces from a few inches to a foot or more in length, and from 1 to 4 inches in thickness, coated with a thin, hard, dark brown bark. The pieces are cylindrical, four-sided, or more or less flattened—sometimes even to the extent of becoming ribbon-like. In transverse section, their structure appears very remarkable. Supposing the piece to be stem, a well-defined pith will be found to occupy the centre of the first-formed wood, which is a column about ¼ of an inch in diameter. This is succeeded by 10 to 15 or more concentric or oftener eccentric zones, ⅒ to ²/₁₀ of an inch wide, each separated from its neighbour by a layer of parenchyme, the outermost being coated with a true bark. In pieces of true root, the pith is reduced to a mere point.

Sometimes the development of the zones has been so irregular that they have formed themselves entirely on one side of the primitive column, the other being coated with bark. The zones, including the layer, around the pith (if pith is present), are crossed by numerous small medullary rays. These do not run from the centre to the circumference, but traverse only their respective zones, on the outside of which they are arched together.

The drug, when of good quality, has its wood firm, compact, and of a dusky yellowish-brown hue, and a well-marked bitter taste. It exhibits under the knife nothing of the close waxy texture seen in the root of Chondodendron, but cuts as a tough, fibrous wood. Its decoction is not tinged blue by iodine. It was in this drug that Wiggers in 1839 discovered pelosine.

The drug just described, which is by no means devoid of medicinal power, has of late years been almost entirely supplanted in the market by another sort consisting exclusively of stems which are devoid of bitterness and appear to be wholly inert. They are in the form of sticks or truncheons, mostly cylindrical. Cut traversely, they display the same structure as the sort last described, with a well-defined pith. The wood is light in weight, of a dull tint, and disposed to split. The bark, which consists of two layers, is easily detached.

3. Stems of Chondodendron tomentosum R. et P.—These have been recently imported from Brazil, and sold as Pareira Brava.[131] The drug consists of truncheons about 1½ feet in length, of a rather rough and knotty stem, from 1 to 4 inches thick.[132] The larger pieces, which are sometimes hollow with age, display, when cut traversely, a small number (5-9) nearly concentric woody zones. The youngest pieces have the bark dotted over with small dark warts.

The wood is inodorous, but has a bitterish taste like the root, of which it is probably an efficient representative. Some pieces have portions of root springing from them, and detached roots occur here and there among the bits of stem. The structure and development of the latter has been elaborately examined and figured by Moss,[133] and also by Lanessan,[134] in the French translation of our book.

4. White Pareira Brava—Stems and roots of Abuta rufescens Aublet.—Mr. J. Correa de Méllo of Campinas has been good enough to send to one of us (H.) a specimen of the root and leaves[135] of this plant, marked Parreira Brava grande. The former we have identified with a drug received from Rio de Janeiro as Abutua Unha de Vaca, i.e. Cowhoof Abutua, and also with a similar drug found in the London market. Aublet[136] states that the root of Abuta rufescens was, in the time of his visit to French Guiana, shipped from that colony to Europe as Pareira Brava Blanc (White Pareira Brava).

This name is well applicable to the drug before us, which consists of short pieces of a root, ½ an inch to 3 inches thick, covered with a rough blackish bark, and also of bits of stem having a pale, striated, corky bark. Cut transversely, the root displays a series of concentric zones of white amylaceous cellular tissue, each beautifully marked with narrow wedge-shaped medullary rays of dark, porous tissue. The wood of the stem is harder than that of the root, the medullary rays are closer together and broader, and there is a distinct pith.

The wood, neither of root nor stem, has any taste or smell. A decoction of the root is turned bright blue by iodine.

5. Yellow Pareira Brava—This drug, of which a quantity was in the hands of a London drug-broker in 1873, is, we presume, the Pareira Brava jaune of Aublet—the bitter tasting stem of his “Abuta amara folio levi cordiformi ligno flavescente,”—a plant of Guiana unknown to recent botanists. That which we have seen consists of portions of a hard woody stem, from 1 to 5 or 6 inches in diameter, covered with a whitish bark. Internally it is marked by numerous regular concentric zones, is of a bright yellow colour and of a bitter taste. It contains berberine. The same drug, apparently, was exhibited in the Paris exposition of 1878 as “Liane amère” from French Guiana.

COCCULUS INDICUS.

Botanical Origin—Anamirta paniculata Colebrooke, 1822 (Menispermum Cocculus L.; Anamirta Cocculus Wight et Arnott, 1834), a strong climbing shrub found in the eastern parts of the Indian peninsula from Concan and Orissa to Malabar and Ceylon, in Eastern Bengal, Khasia and Assam, and in the Malayan Islands.

History—It is commonly asserted that Cocculus Indicus was introduced into Europe through the Arabs, but the fact is difficult of proof; for though Avicenna[137] and other early writers mention a drug having the power of poisoning fish, they describe it as a bark, and make no allusion to it as a production of India. Even Ibn Baytar[138] in the 13th century professed his inability to discover what substance the older Arabian authors had in view.

Cocculus Indicus is not named by the writers of the School of Salerno. The first mention of it we have met with is by Ruellius,[139] who, alluding to the property possessed by the roots of Aristolochia and Cyclamen of attracting fishes, states that the same power exists in the little berries found in the shops under the name of Cocci Orientis, which when scattered on water stupify the fishes, so that they may be captured by the hand.

Valerius Cordus[140] thought the drug which he calls Cuculi de Levante to be the fruit of a Solanum growing in Egypt.

Dalechamps[141] repeated this statement in 1586, at which period and for long afterwards, Cocculus Indicus used to reach Europe from Alexandria and other parts of the Levant. Gerarde,[142] who gives a very good figure of it, says it is well known in England (1597) as Cocculus Indicus, otherwise Cocci vel Cocculæ Orientales, and that it is used for destroying vermin and poisoning fish. In 1635 it was subject to an import duty of 2s. per lb., as Cocculus Indiæ.[143]

The use of Cocculus Indicus in medicine was advocated by Battista Codronchi, a celebrated Italian physician of the 16th century, in a tractate entitled De Baccis Orientalibus.[144] In the “Pinax” Caspar Bauhin (about 1660) states that Cocculæ officinarum “saepe racematim pediculis hærentes, hederæ corymborum modo, ex Alexandria adferuntur.”

The word Cocculus is derived from the Italian coccola, signifying a small, berry-like fruit.[145] Mattioli remarks that as the berries when first brought from the East to Italy had no special name, they got to be called Coccole di Levante.[146]

Description—The female flower of Anamirta has normally 5 ovaries placed on a short gynophore. The latter, as it grows, becomes raised into a stalk about ½ an inch long, articulated at the summit with shorter stalks, each supporting a drupe, which is a matured ovary. The purple drupes thus produced are 1 to 3 in number, of gibbous ovoid form, with the persistent stigma on the straight side, and in a line with the shorter stalk or carpodium. They grow in a pendulous panicle, a foot or more in length.

These fruits removed from their stalks and dried have the aspect of little round berries, and constitute the Cocculus Indicus of commerce. As met with in the market they are shortly ovoid or subreniform, ⁴/₁₀ to ⁵/₁₀ of an inch long, with a blackish, wrinkled surface, and an obscure ridge running round the back. The shorter stalk, when present, supports the fruit very obliquely. The pericarp, consisting of a wrinkled skin covering a thin woody endocarp, encloses a single reniform seed, into which the endocarp deeply intrudes. In transverse section the seed has a horseshoe form; it consists chiefly of albumen, enclosing a pair of large, diverging lanceolate cotyledons, with a short terete radicle.[147]

The seed is bitter and oily, the pericarp tasteless. The drug is preferred when of dark colour, free from stalks, and fresh, with the seeds well-preserved.

Microscopic Structure—The woody endocarp is built up of a peculiar sclerenchymatous tissue, consisting of branched, somewhat elongated cells. They are densely packed, and run in various directions, showing but small cavities. The parenchyme of the seed is loaded with crystallized fatty matter.

Chemical Composition—Picrotoxin, a crystallizable substance occurring in the seed to the extent of ⅖ to 1 per cent., was observed by Boullay, as early as 1812, and is the source of the poisonous property of the drug. Picrotoxin does not neutralize acids. It dissolves in water and in alkalis; the solution in the latter reduces cupric or bismutic oxide like the sugars, but to a much smaller extent than glucose. The alcoholic solutions deviate the ray of polarized light to the left. The aqueous solution of picrotoxin is not altered by any metallic salt, or by tannin, iodic acid, iodohydrargyrate or bichromate of potassium—in fact by none of the reagents which affect the alkaloids. It may thus be easily distinguished from the bitter poisonous alkaloids, although in its behaviour with concentrated sulphuric acid and bichromate of potassium it somewhat resembles strychnine, as shown in 1867 by Köhler.

Picrotoxin melts at 200° C.; its composition, C₉H₁₀O₄, as ascertained in 1877 by Paternò and Oglialoro, is the same as that of everninic, hydrocoffeïc, umbellic and veratric (or dimethyl-protocatechuic acid—see Semen Sabadillæ) acids.

Pelletier and Couerbe (1833) obtained from the pericarp of Cocculus Indicus two crystallizable, tasteless, non-poisonous substances, having the same composition, and termed respectively Menispermine and Paramenispermine. These bodies, as well as the very doubtful amorphous Hypopicrotoxic Acid of the same chemists, require re-examination.

The fat of the seed, which amounts to about half its weight, is used in India for industrial purposes. Its acid constituent, formerly regarded as a peculiar substance under the name of Stearophanic or Anamirtic Acid, was found by Heintz to be identical with stearic acid.

Commerce—Cocculus Indicus is imported from Bombay and Madras, but we have no statistics showing to what extent. The stock in the dock warehouses of London on 1st of December, 1873, was 1168 packages, against 2010 packages on the same day of the previous year. The drug is mostly shipped to the Continent, the consumption in Great Britain being very small.

Uses—In British medicine Cocculus Indicus is only employed as an ingredient of an ointment for the destruction of pediculi. It has been discarded from the British Pharmacopœia, but has a place in that of India.

GULANCHA.

Caulis et radix Tinosporæ.

Botanical Origin—Tinospora cordifolia Miers (Cocculus cordifolius DC.), a lofty climbing shrub found throughout tropical India from Kumaon to Assam and Burma, and from Concan to Ceylon and the Carnatic.[148] It is called in Hindustani Gulancha; in Bombay the drug is known under the name of Goolwail.

History—The virtues of this plant which appear to have been long familiar to the Hindu physicians, attracted the attention of Europeans in India at the early part of the present century.[149] According to a paper published at Calcutta in 1827,[150] the parts used are the stem, leaves, and root, which are given in decoction, infusion, or a sort of extract called pálo, in a variety of diseases attended with slight febrile symptoms.

O’Shaughnessy declares the plant to be one of the most valuable in India, and that it has proved a very useful tonic. Similar favourable testimony is borne by Waring. Gulancha was admitted to the Bengal Pharmacopœia of 1844, and to the Pharmacopœia of India of 1868.

Description—The stems are perennial, twining and succulent, running over the highest trees and throwing out roots many yards in length which descend like slender cords to the earth. They have a thick corky bark marked with little prominent tubercles.

As found in the bazaars the drug occurs as short transverse segments of a cylindrical woody stem from ¼ of an inch up to 2 inches in diameter. They exhibit a shrunken appearance, especially those derived from the younger stems, and are covered with a smooth, translucent, shrivelled bark which becomes dull and rugose with age. Many of the pieces are marked with warty prominences and the scars of adventitious roots. The outer layer which is easily detached covers a shrunken parenchyme. The transverse section of the stem shows it to be divided by about 12 to 14 medullary rays into the same number of wedge-shaped woody bundles having very large vessels, but no concentric structure. The drug is inodorous but has a very bitter taste. The root is stated by O’Shaughnessy[151] to be large, soft, and spongy.

Microscopic Structure—The suberous coat consists of alternating layers of flat corky cells and sclerenchyme, sometimes of a yellow colour. The structure of the central part reminds one of that of Cissampelos Pareira (p. 28), like which it is not divided into concentric zones. The woody rays which are sometimes intersected by parenchyme, are surrounded by a loose circle of arched bundles of liber tissue.

Chemical Composition—No analysis worthy of the name has been made of this drug, and the nature of its bitter principle is wholly unknown. We have had no material at our disposal sufficient for chemical examination.

Uses—Gulancha is reputed to be tonic, antiperiodic and diuretic. According to Waring[152] it is useful in mild forms of intermittent fever, in debility after fevers and other exhausting diseases, in secondary syphilitic affections and chronic rheumatism.

Substitute—Tinospora crispa Miers, an allied species occurring in Silhet, Pegu, Java, Sumatra, and the Philippines, possesses similar properties, and is highly esteemed in the Indian Archipelago as a febrifuge.